Tryptophan is an essential nutrient required to generate vitamin B3 (niacin), which is mainly
involved in energy metabolism and DNA production. Alterations in tryptophan metabolism …

Maintaining mitochondrial homeostasis is a potential therapeutic strategy for various
diseases, including neurodegenerative diseases, cardiovascular diseases, metabolic …

Postmenopausal osteoporosis is recognized to be one of the major skeleton diseases
strongly associated with impaired bone formation. Previous reports have indicated that the …

Mitochondrial dysfunction plays a crucial role in the development of glucocorticoid-induced
osteoporosis (GIO). Cytidine monophosphate kinase 2 (Cmpk2), an essential mitochondria …

Background Senile osteoporosis (SOP) is an age-related metabolic bone disease that
currently lacks specific therapeutic interventions. Thus, this study aimed to investigate the …

Bone homeostasis depends on a precise dynamic balance between bone resorption and
bone formation, involving a series of complex and highly regulated steps. Any imbalance in …

Accumulating evidence has suggested a strong correlation between age‐related bone
diseases and abnormal metabolism of bone microenvironment‐related cells, including …

The process of skeletal regeneration initiated by stem cells following injury, especially in
fractures, is significantly impaired by aging and adverse factors. Nicotinamide …

By 2060, an estimated one in four Americans will be elderly. Consequently, the prevalence
of osteoporosis and fragility fractures will also increase. Presently, no available intervention …

Human aging is linked to bone loss, resulting in bone fragility and an increased risk of
fractures. This is primarily due to an age-related decline in the function of bone-forming …