The successful landmark discovery of mouse and human inducible pluripotential stem cells
(iPSC's) by Takahashi and Yamanaka in 2006 and 2007 has triggered a revolution in the …

Cell‐based therapies suggest novel treatments to overcome the complication of the current
therapeutic approaches in diabetes mellitus type 1. Replacement of the destroyed …

Aims New sources of insulin-secreting cells are strongly required for the cure of diabetes.
Recent successes in differentiating embryonic stem cells, in combination with the discovery …

Diabetes mellitus (DM) is a group of metabolic disorders characterized by high blood
glucose levels due to insufficient insulin secretion, insulin action, or both. The present-day …

Pluripotent stem cells have potential applications in regenerative medicine for diabetes.
Differentiation of stem cells into insulin-producing cells has been achieved using various …

Embryonic stem cell differentiation models have increasingly been applied in non-animal
test systems for developmental toxicity. After the initial focus on cardiac differentiation …

Bioencapsulation technologies have played an important role in the developing successes
of tissue engineering. Besides offering immunoisolation, they also show promise for …

Protein transduction using cell-penetrating peptides (CPPs) is useful for the delivery of large
protein molecules, including some transcription factors. This method is safer than gene …

According to the figures released by the International Diabetes Federation (IDF), there were
more than 4.8 million diabetes-related deaths in 2012 alone, and a total of 371 million …

Induced pluripotent stem cells (iPSC) are somatic cells reprogrammed to pluripotency by
forced expression of pluripotency factors. These cells are shown to have the same …