Antigen presentation in cancer—mechanisms and clinical implications for immunotherapy
Over the past decade, the emergence of effective immunotherapies has revolutionized the
clinical management of many types of cancers. However, long-term durable tumour control …
clinical management of many types of cancers. However, long-term durable tumour control …
Hallmarks of the aging T‐cell system
The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …
Improved prediction of immune checkpoint blockade efficacy across multiple cancer types
Only a fraction of patients with cancer respond to immune checkpoint blockade (ICB)
treatment, but current decision-making procedures have limited accuracy. In this study, we …
treatment, but current decision-making procedures have limited accuracy. In this study, we …
Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty
Frailty is an intermediate status of the human aging process, associated with
decompensated homeostasis and death. The immune phenotype of frailty and its underlying …
decompensated homeostasis and death. The immune phenotype of frailty and its underlying …
The immuneML ecosystem for machine learning analysis of adaptive immune receptor repertoires
Adaptive immune receptor repertoires (AIRR) are key targets for biomedical research as
they record past and ongoing adaptive immune responses. The capacity of machine …
they record past and ongoing adaptive immune responses. The capacity of machine …
[PDF][PDF] Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
S Meyer, I Blaas, RC Bollineni, M Delic-Sarac, TT Tran… - Cell reports, 2023 - cell.com
The emergence of SARS-CoV-2 variants of concern (VOC) is driven by mutations that
mediate escape from neutralizing antibodies. There is also evidence that mutations can …
mediate escape from neutralizing antibodies. There is also evidence that mutations can …
The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders
Idiopathic aplastic anemia (IAA) is a rare autoimmune bone marrow failure (BMF) disorder
initiated by a human leukocyte antigen (HLA)-restricted T-cell response to unknown …
initiated by a human leukocyte antigen (HLA)-restricted T-cell response to unknown …
Benefit and toxicity of programmed death‐1 blockade vary by ethnicity in patients with advanced melanoma: an international multicentre observational study
Background Programmed cell death receptor‐1 (PD‐1) monotherapy is a standard treatment
for advanced cutaneous melanoma, but its efficacy and toxicity are defined in white …
for advanced cutaneous melanoma, but its efficacy and toxicity are defined in white …
[HTML][HTML] Next-generation sequencing: unraveling genetic mechanisms that shape cancer immunotherapy efficacy
Immunity is governed by fundamental genetic processes. These processes shape the nature
of immune cells and set the rules that dictate the myriad complex cellular interactions that …
of immune cells and set the rules that dictate the myriad complex cellular interactions that …
[HTML][HTML] The innate immune system in human kidney inflammaging
Elderly individuals with chronic disorders tend to develop inflammaging, a condition
associated with elevated levels of blood inflammatory markers, and increased susceptibility …
associated with elevated levels of blood inflammatory markers, and increased susceptibility …