Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
A Mitrofanova, S Merscher, A Fornoni - Nature Reviews Nephrology, 2023 - nature.com
Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …
prevalence. Among several pathogenetic mechanisms responsible for disease progression …
Dyslipidaemia in nephrotic syndrome: mechanisms and treatment
S Agrawal, JJ Zaritsky, A Fornoni… - Nature Reviews …, 2018 - nature.com
Nephrotic syndrome is a highly prevalent disease that is associated with high morbidity
despite notable advances in its treatment. Many of the complications of nephrotic syndrome …
despite notable advances in its treatment. Many of the complications of nephrotic syndrome …
Whole exome sequencing of patients with steroid-resistant nephrotic syndrome
JK Warejko, W Tan, A Daga, D Schapiro… - Clinical Journal of the …, 2018 - journals.lww.com
Results In 74 of 300 families (25%), we identified a causative mutation in one of 20 genes
known to cause steroid-resistant nephrotic syndrome. In 11 families (3.7%), we detected a …
known to cause steroid-resistant nephrotic syndrome. In 11 families (3.7%), we detected a …
Care4Rare Canada: Outcomes from a decade of network science for rare disease gene discovery
The past decade has witnessed a rapid evolution in rare disease (RD) research, fueled by
the availability of genome-wide (exome and genome) sequencing. In 2011, as this …
the availability of genome-wide (exome and genome) sequencing. In 2011, as this …
A rheostat of ceramide and sphingosine-1-phosphate as a determinant of oxidative stress-mediated kidney injury
N Ueda - International journal of molecular sciences, 2022 - mdpi.com
Reactive oxygen species (ROS) modulate sphingolipid metabolism, including enzymes that
generate ceramide and sphingosine-1-phosphate (S1P), and a ROS-antioxidant rheostat …
generate ceramide and sphingosine-1-phosphate (S1P), and a ROS-antioxidant rheostat …
Sphingolipid biosynthesis in man and microbes
A new review covering up to 2018 Sphingolipids are essential molecules that, despite their
long history, are still stimulating interest today. The reasons for this are that, as well as …
long history, are still stimulating interest today. The reasons for this are that, as well as …
State-of-the-art iron-based nanozymes for biocatalytic tumor therapy
M Li, H Zhang, Y Hou, X Wang, C Xue, W Li, K Cai… - Nanoscale …, 2020 - pubs.rsc.org
Biocatalytic tumor therapy with artificial nanoscale enzyme-mimics (nanozymes) is an
emerging strategy for the therapeutic intervention of a variety of malignant conditions, which …
emerging strategy for the therapeutic intervention of a variety of malignant conditions, which …
Finding a way out: S1P signaling and immune cell migration
AAL Baeyens, SR Schwab - Annual review of immunology, 2020 - annualreviews.org
The signaling lipid sphingosine 1-phosphate (S1P) plays critical roles in an immune
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …
response. Drugs targeting S1P signaling have been remarkably successful in treatment of …
Mutations in six nephrosis genes delineate a pathogenic pathway amenable to treatment
No efficient treatment exists for nephrotic syndrome (NS), a frequent cause of chronic kidney
disease. Here we show mutations in six different genes (MAGI2, TNS2, DLC1, CDK20 …
disease. Here we show mutations in six different genes (MAGI2, TNS2, DLC1, CDK20 …