Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the
millions of affected individuals. Progressive memory impairment in AD patients is associated …

The hippocampus, a brain area critical for learning and memory, is especially vulnerable to
damage at early stages of Alzheimer's disease (AD). Emerging evidence has indicated that …

In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …

Neurogenesis persists during adulthood in the dentate gyrus of the hippocampus. Signals
provided by the local hippocampal microenvironment support neural stem cell proliferation …

Brain plasticity refers to the remarkable property of cerebral neurons to change their
structure and function in response to experience, a fundamental theoretical theme in the …

Targeting the amyloid‐β (Aβ) peptide cascade has been at the heart of therapeutic
developments in Alzheimer's disease (AD) research for more than 25 years, yet no …

Cognitive reserve, broadly conceived, encompasses aspects of brain structure and function
that optimize individual performance in the presence of injury or pathology. Reserve is …

In this review, we consider the evidence that a reduction in neurogenesis underlies aging-
related cognitive deficits and impairments in disorders such as Alzheimer's disease (AD) …

Alzheimer's disease (AD) is an age‐related neurodegenerative disorder characterized by
aggregation of toxic forms of amyloid β peptide (Aβ). Treatment strategies have largely been …

Stress often occurs during toxicity studies. The perception of sensory stimuli as stressful
primarily results in catecholamine release and activation of the hypothalamic–pituitary …