Neurotransmitters: emerging targets in cancer

SH Jiang, LP Hu, X Wang, J Li, ZG Zhang - Oncogene, 2020 - nature.com
Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …

[HTML][HTML] Neuropeptide Y peptide family and cancer: Antitumor therapeutic strategies

ML Sánchez, FD Rodríguez, R Coveñas - International Journal of …, 2023 - mdpi.com
Currently available data on the involvement of neuropeptide Y (NPY), peptide YY (PYY), and
pancreatic polypeptide (PP) and their receptors (YRs) in cancer are updated. The structure …

[HTML][HTML] Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway

S Kumar, A Nandi, S Singh, R Regulapati, N Li… - Nature …, 2021 - nature.com
Abstract Development of chemoresistance in breast cancer patients greatly increases
mortality. Thus, understanding mechanisms underlying breast cancer resistance to …

[HTML][HTML] Developing targeted therapies for neuroblastoma by dissecting the effects of metabolic reprogramming on tumor microenvironments and progression

W Jin, Y Zhang, Z Zhao, M Gao - Theranostics, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Synergic reprogramming of metabolic dominates neuroblastoma (NB)
progression. It is of great clinical implications to develop an individualized risk …

[HTML][HTML] Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma

C Lu, A Mahajan, SH Hong, S Galli, S Zhu… - Nature …, 2022 - nature.com
Adverse prognosis in Ewing sarcoma (ES) is associated with the presence of metastases,
particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic …

[HTML][HTML] Neuropeptide Y and its receptors in prostate cancer: associations with cancer invasiveness and perineural spread

D Sigorski, W Wesołowski, A Gruszecka… - Journal of Cancer …, 2023 - Springer
Abstract Purpose Neuropeptide Y (NPY) is a pleiotropic peptide, which is involved in many
biological mechanisms important in regulation of cell growth and survival. The aim of this …

[HTML][HTML] Preclinical Models of Neuroblastoma—Current Status and Perspectives

E Krawczyk, J Kitlińska - Cancers, 2023 - mdpi.com
Simple Summary Neuroblastoma is a pediatric tumor originating from the precursors of
sympathetic nerves. The disease is known for its high heterogeneity. Hence, developing …

Detection of glycine as a model protein in blood serum using 2D-IR spectroscopy

SH Rutherford, GM Greetham, PM Donaldson… - Analytical …, 2020 - ACS Publications
Glycine (Gly) is used as a model system to evaluate the ability of ultrafast two-dimensional
infrared (2D-IR) spectroscopy to detect and quantify the low-molecular-weight proteinaceous …

[HTML][HTML] An insight into neuropeptides inhibitors in the biology of colorectal cancer: Opportunity and translational perspectives

A Srivastava, D Rikhari, B Pradhan, KK Bharadwaj… - Applied Sciences, 2022 - mdpi.com
Neuropeptides are mainly secreted from the human central and peripheral nervous systems.
Neuropeptides bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) and …

[HTML][HTML] Neuropeptide Y/Y5 receptor pathway stimulates neuroblastoma cell motility through RhoA activation

N Abualsaud, L Caprio, S Galli, E Krawczyk… - Frontiers in Cell and …, 2021 - frontiersin.org
Neuropeptide Y (NPY) has been implicated in the regulation of cellular motility under
various physiological and pathological conditions, including cancer dissemination. Yet, the …