Neurotransmitters: emerging targets in cancer
Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …
[HTML][HTML] Neuropeptide Y peptide family and cancer: Antitumor therapeutic strategies
ML Sánchez, FD Rodríguez, R Coveñas - International Journal of …, 2023 - mdpi.com
Currently available data on the involvement of neuropeptide Y (NPY), peptide YY (PYY), and
pancreatic polypeptide (PP) and their receptors (YRs) in cancer are updated. The structure …
pancreatic polypeptide (PP) and their receptors (YRs) in cancer are updated. The structure …
[HTML][HTML] Dll1+ quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway
Abstract Development of chemoresistance in breast cancer patients greatly increases
mortality. Thus, understanding mechanisms underlying breast cancer resistance to …
mortality. Thus, understanding mechanisms underlying breast cancer resistance to …
[HTML][HTML] Developing targeted therapies for neuroblastoma by dissecting the effects of metabolic reprogramming on tumor microenvironments and progression
W Jin, Y Zhang, Z Zhao, M Gao - Theranostics, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Synergic reprogramming of metabolic dominates neuroblastoma (NB)
progression. It is of great clinical implications to develop an individualized risk …
progression. It is of great clinical implications to develop an individualized risk …
[HTML][HTML] Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma
Adverse prognosis in Ewing sarcoma (ES) is associated with the presence of metastases,
particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic …
particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic …
[HTML][HTML] Neuropeptide Y and its receptors in prostate cancer: associations with cancer invasiveness and perineural spread
D Sigorski, W Wesołowski, A Gruszecka… - Journal of Cancer …, 2023 - Springer
Abstract Purpose Neuropeptide Y (NPY) is a pleiotropic peptide, which is involved in many
biological mechanisms important in regulation of cell growth and survival. The aim of this …
biological mechanisms important in regulation of cell growth and survival. The aim of this …
[HTML][HTML] Preclinical Models of Neuroblastoma—Current Status and Perspectives
E Krawczyk, J Kitlińska - Cancers, 2023 - mdpi.com
Simple Summary Neuroblastoma is a pediatric tumor originating from the precursors of
sympathetic nerves. The disease is known for its high heterogeneity. Hence, developing …
sympathetic nerves. The disease is known for its high heterogeneity. Hence, developing …
Detection of glycine as a model protein in blood serum using 2D-IR spectroscopy
Glycine (Gly) is used as a model system to evaluate the ability of ultrafast two-dimensional
infrared (2D-IR) spectroscopy to detect and quantify the low-molecular-weight proteinaceous …
infrared (2D-IR) spectroscopy to detect and quantify the low-molecular-weight proteinaceous …
[HTML][HTML] An insight into neuropeptides inhibitors in the biology of colorectal cancer: Opportunity and translational perspectives
A Srivastava, D Rikhari, B Pradhan, KK Bharadwaj… - Applied Sciences, 2022 - mdpi.com
Neuropeptides are mainly secreted from the human central and peripheral nervous systems.
Neuropeptides bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) and …
Neuropeptides bind to its cognate rhodopsin-like G-protein coupled receptor (GPCR) and …
[HTML][HTML] Neuropeptide Y/Y5 receptor pathway stimulates neuroblastoma cell motility through RhoA activation
N Abualsaud, L Caprio, S Galli, E Krawczyk… - Frontiers in Cell and …, 2021 - frontiersin.org
Neuropeptide Y (NPY) has been implicated in the regulation of cellular motility under
various physiological and pathological conditions, including cancer dissemination. Yet, the …
various physiological and pathological conditions, including cancer dissemination. Yet, the …