An update on rhabdomyosarcoma risk stratification and the rationale for current and future Children's Oncology Group clinical trials
JH Haduong, CM Heske… - Pediatric blood & …, 2022 - Wiley Online Library
Children and adolescents with rhabdomyosarcoma (RMS) comprise a heterogeneous
population with variable overall survival rates ranging between approximately 6% and 100 …
population with variable overall survival rates ranging between approximately 6% and 100 …
[HTML][HTML] Rhabdomyosarcoma: current therapy, challenges, and future approaches to treatment strategies
Simple Summary Rhabdomyosarcoma (RMS) is a rare pediatric sarcoma affecting skeletal
muscle in children and young adults. It is responsible for 3% of all childhood malignant …
muscle in children and young adults. It is responsible for 3% of all childhood malignant …
Crosstalk between hedgehog and other signaling pathways as a basis for combination therapies in cancer
J Brechbiel, K Miller-Moslin, AA Adjei - Cancer treatment reviews, 2014 - Elsevier
The hedgehog (Hh) pathway is aberrantly activated in a number of tumors. In
medulloblastoma, basal cell carcinoma, and rhabdomyosarcoma, mutations in Hh pathway …
medulloblastoma, basal cell carcinoma, and rhabdomyosarcoma, mutations in Hh pathway …
Sonic hedgehog signaling in Basal cell nevus syndrome
M Athar, C Li, AL Kim, VS Spiegelman, DR Bickers - Cancer research, 2014 - AACR
The hedgehog (Hh) signaling pathway is considered to be a major signal transduction
pathway during embryonic development, but it usually shuts down after birth. Aberrant Sonic …
pathway during embryonic development, but it usually shuts down after birth. Aberrant Sonic …
[HTML][HTML] Crosstalk of hedgehog and mTORC1 pathways
LJ Larsen, LB Møller - Cells, 2020 - mdpi.com
Hedgehog (Hh) signaling and mTOR signaling, essential for embryonic development and
cellular metabolism, are both coordinated by the primary cilium. Observations from cancer …
cellular metabolism, are both coordinated by the primary cilium. Observations from cancer …
Signaling pathways in Rhabdomyosarcoma invasion and metastasis
Rhabdomyosarcoma (RMS) is an aggressive childhood mesenchymal tumor with two major
molecular and histopathologic subtypes: fusion-positive (FP) RMS, characterized by the …
molecular and histopathologic subtypes: fusion-positive (FP) RMS, characterized by the …
Targeting Hedgehog signaling pathway: paving the road for cancer therapy
A Salaritabar, I Berindan-Neagoe, B Darvish… - Pharmacological …, 2019 - Elsevier
The Hedgehog pathway is essential for embryonic development but also for tissue and
organ homeostasis in adult organisms. Activation of this pathway leads to the expression of …
organ homeostasis in adult organisms. Activation of this pathway leads to the expression of …
Rhabdomyosarcoma: advances in molecular and cellular biology
X Sun, W Guo, JK Shen, HJ Mankin, FJ Hornicek… - Sarcoma, 2015 - Wiley Online Library
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and
adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the …
adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the …
[HTML][HTML] GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis
Rhabdomyosarcoma (RMS) typically arises from skeletal muscle. Currently, RMS in patients
with recurrent and metastatic disease have no successful treatment. The molecular …
with recurrent and metastatic disease have no successful treatment. The molecular …
[HTML][HTML] Aberrant GLI1 activation in DNA damage response, carcinogenesis and chemoresistance
The canonical hedgehog (HH) pathway is a multicomponent signaling cascade (HH, protein
patched homolog 1 (PTCH1), smoothened (SMO)) that plays a pivotal role during embryonic …
patched homolog 1 (PTCH1), smoothened (SMO)) that plays a pivotal role during embryonic …