Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …

Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

This paper introduces a new construct, the 'pivotal mental state', which is defined as a hyper-
plastic state aiding rapid and deep learning that can mediate psychological transformation …

Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

Serotonin 5-HT2A receptors (5-HT2ARs) are widely distributed in the central nervous
system, especially in brain region essential for learning and cognition. In addition to …

Abstract Serotonergic hallucinogens, such as (+)-lysergic acid diethylamide, psilocybin, and
mescaline, are somewhat enigmatic substances. Although these drugs are derived from …

Introduction Taking microdoses (a mere fraction of normal doses) of psychedelic
substances, such as truffles, recently gained popularity, as it allegedly has multiple …

Background The amygdala is a key structure in serotonergic emotion-processing circuits. In
healthy volunteers, acute administration of the serotonin 1A/2A/2C receptor agonist …

Psychedelic drugs, such as lysergic acid diethylamide (LSD), mescaline, and psilocybin,
exert profound effects on brain and behavior. After decades of difficulties in studying these …