[HTML][HTML] Tat is a multifunctional viral protein that modulates cellular gene expression and functions
The human immunodeficiency virus type I (HIV-1) has developed several strategies to
condition the host environment to promote viral replication and spread. Viral proteins have …
condition the host environment to promote viral replication and spread. Viral proteins have …
Current research on viral proteins that interact with fibrillarin
S Decle-Carrasco, AL Rodríguez-Piña… - Molecular Biology …, 2023 - Springer
The nucleolus is a multifunctional nuclear domain primarily dedicated to ribosome
biogenesis. Certain viruses developed strategies to manipulate host nucleolar proteins to …
biogenesis. Certain viruses developed strategies to manipulate host nucleolar proteins to …
Large-scale quality analysis of published ChIP-seq data
ChIP-seq has become the primary method for identifying in vivo protein–DNA interactions on
a genome-wide scale, with nearly 800 publications involving the technique appearing in …
a genome-wide scale, with nearly 800 publications involving the technique appearing in …
[HTML][HTML] HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production
R El-Amine, D Germini, VV Zakharova, T Tsfasman… - Redox biology, 2018 - Elsevier
Human immunodeficiency virus (HIV) infection is associated with B-cell malignancies in
patients though HIV-1 is not able to infect B-cells. The rate of B-cell lymphomas in HIV …
patients though HIV-1 is not able to infect B-cells. The rate of B-cell lymphomas in HIV …
The lncRNA PRINS-miRNA-mRNA axis gene expression profile as a circulating biomarker panel in psoriasis
HY Abdallah, NZ Tawfik, NH Soliman… - Molecular Diagnosis & …, 2022 - Springer
Background The interaction between genes and the environment in psoriasis is firmly
coupled by epigenetic modification. Epigenetic modifications are inherited variations in gene …
coupled by epigenetic modification. Epigenetic modifications are inherited variations in gene …
HIV Tat induces a prolonged MYC relocalization next to IGH in circulating B-cells
D Germini, T Tsfasman, M Klibi, R El-Amine, A Pichugin… - Leukemia, 2017 - nature.com
With combined antiretroviral therapy (cART), the risk for HIV-infected individuals to develop
a non-Hodgkin lymphoma is diminished. However, the incidence of Burkitt lymphoma (BL) …
a non-Hodgkin lymphoma is diminished. However, the incidence of Burkitt lymphoma (BL) …
HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells
HIV encodes Tat, a small protein that facilitates viral transcription by binding an RNA
structure (trans-activating RNA [TAR]) formed on nascent viral pre-messenger RNAs …
structure (trans-activating RNA [TAR]) formed on nascent viral pre-messenger RNAs …
Global pairwise RNA interaction landscapes reveal core features of protein recognition
RNA–protein interactions permeate biology. Transcription, translation, and splicing all hinge
on the recognition of structured RNA elements by RNA-binding proteins. Models of RNA …
on the recognition of structured RNA elements by RNA-binding proteins. Models of RNA …
Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus
MA Jarboui, C Bidoia, E Woods, B Roe, K Wynne… - PLoS …, 2012 - journals.plos.org
The trans-activator Tat protein is a viral regulatory protein essential for HIV-1 replication. Tat
trafficks to the nucleoplasm and the nucleolus. The nucleolus, a highly dynamic and …
trafficks to the nucleoplasm and the nucleolus. The nucleolus, a highly dynamic and …
Suicide gene therapy in cancer and HIV-1 infection: An alternative to conventional treatments
Abstract Suicide Gene Therapy (SGT) aims to introduce a gene encoding either a toxin or an
enzyme making the targeted cell more sensitive to chemotherapy. SGT represents an …
enzyme making the targeted cell more sensitive to chemotherapy. SGT represents an …