[HTML][HTML] Natural killer T cells in cancer immunotherapy
S Nair, MV Dhodapkar - Frontiers in immunology, 2017 - frontiersin.org
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …
Immune suppression and reversal of the suppressive tumor microenvironment
K Shimizu, T Iyoda, M Okada… - International …, 2018 - academic.oup.com
Most tumors employ multiple strategies to attenuate T-cell-mediated immune responses. In
particular, immune suppression surrounding the tumor is achieved by interfering with …
particular, immune suppression surrounding the tumor is achieved by interfering with …
The role of NKT cells in tumor immunity
M Terabe, JA Berzofsky - Advances in cancer research, 2008 - Elsevier
NKT cells are a relatively newly recognized member of the immune community, with
profound effects on the rest of the immune system despite their small numbers. They are true …
profound effects on the rest of the immune system despite their small numbers. They are true …
[HTML][HTML] Innate Invariant NKT Cells Recognize Mycobacterium tuberculosis–Infected Macrophages, Produce Interferon-γ, and Kill Intracellular Bacteria
I Sada-Ovalle, A Chiba, A Gonzales, MB Brenner… - PLoS …, 2008 - journals.plos.org
Cellular immunity to Mycobacterium tuberculosis (Mtb) requires a coordinated response
between the innate and adaptive arms of the immune system, resulting in a type 1 cytokine …
between the innate and adaptive arms of the immune system, resulting in a type 1 cytokine …
The regulatory role of invariant NKT cells in tumor immunity
RM McEwen-Smith, M Salio, V Cerundolo - Cancer immunology research, 2015 - AACR
Invariant natural killer T (iNKT) cells are a unique population of T lymphocytes, which lie at
the interface between the innate and adaptive immune systems, and are important …
the interface between the innate and adaptive immune systems, and are important …
Immune networks and therapeutic targeting of iNKT cells in cancer
SI Fujii, K Shimizu - Trends in Immunology, 2019 - cell.com
One of the primary goals in tumor immunotherapy is to reset the immune system from
tolerogenic to immunogenic–a process in which invariant natural killer T (iNKT) cells are …
tolerogenic to immunogenic–a process in which invariant natural killer T (iNKT) cells are …
[HTML][HTML] α-GalCer and iNKT cell-based cancer immunotherapy: realizing the therapeutic potentials
NKT cells are CD1d-restricted innate-like T cells expressing both T cell receptor and NK cell
markers. The major group of NKT cells in both human and mice is the invariant NKT (iNKT) …
markers. The major group of NKT cells in both human and mice is the invariant NKT (iNKT) …
[HTML][HTML] Regulation of NKT cell localization in homeostasis and infection
D Slauenwhite, B Johnston - Frontiers in immunology, 2015 - frontiersin.org
Natural killer T (NKT) cells are a specialized subset of T lymphocytes that regulate immune
responses in the context of autoimmunity, cancer, and microbial infection. Lipid antigens …
responses in the context of autoimmunity, cancer, and microbial infection. Lipid antigens …
Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency
G Wingender, P Krebs, B Beutler… - The Journal of …, 2010 - journals.aai.org
Invariant NKT (iNKT) cells are a unique subset of T lymphocytes that rapidly carry out
effector functions following activation with glycolipid Ags, such as the model Ag α …
effector functions following activation with glycolipid Ags, such as the model Ag α …
Immunosuppressive myeloid-derived suppressor cells can be converted into immunogenic APCs with the help of activated NKT cells: an alternative cell-based …
HJ Ko, JM Lee, YJ Kim, YS Kim, KA Lee… - The Journal of …, 2009 - journals.aai.org
Myeloid-derived suppressor cells (MDSCs), which are known to be accumulated in the
blood, spleen, and bone marrow of tumor-bearing mice and cancer patients, were tested as …
blood, spleen, and bone marrow of tumor-bearing mice and cancer patients, were tested as …