Are inhibitors of histone deacetylase 8 (HDAC8) effective in hematological cancers especially acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) …
Abstract Histone deacetylase 8 (HDAC8) aberrantly deacetylates histone and non-histone
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …
proteins. These include structural maintenance of chromosome 3 (SMC3) cohesin protein …
2-Aminobenzothiazoles in anticancer drug design and discovery
G Huang, T Cierpicki, J Grembecka - Bioorganic chemistry, 2023 - Elsevier
Cancer is one of the major causes of mortality and morbidity worldwide. Substantial
research efforts have been made to develop new chemical entities with improved anticancer …
research efforts have been made to develop new chemical entities with improved anticancer …
A therapeutic perspective of HDAC8 in different diseases: an overview of selective inhibitors
Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional
repression and chromatin condensation mechanisms by removing the acetyl moiety from …
repression and chromatin condensation mechanisms by removing the acetyl moiety from …
Synthesis, antitumor, and apoptosis-inducing activities of novel 5-arylidenethiazolidine-2, 4-dione derivatives: histone deacetylases inhibitory activity and molecular …
The antitumor activity of the newly synthesized 5-arylidenethiazolidine-2, 4-dione derivatives
18a–f and 19a–f was investigated, compared to doxorubicin (IC 50= 4.17–8.87 μM) and …
18a–f and 19a–f was investigated, compared to doxorubicin (IC 50= 4.17–8.87 μM) and …
Integrated fragment-based drug design and virtual screening techniques for exploring the antidiabetic potential of thiazolidine-2, 4-diones: Design, synthesis and in …
Diabetes mellitus is a metabolic disorder characterized by elevated blood sugar levels and
related complications. This study focuses on harnessing and integrating fragment-based …
related complications. This study focuses on harnessing and integrating fragment-based …
Thiazolidin-2, 4-dione scaffold: an insight into recent advances as antimicrobial, antioxidant, and hypoglycemic agents
Heterocyclic compounds containing nitrogen and sulfur, especially those in the thiazole
family, have generated special interest in terms of their synthetic chemistry, which is …
family, have generated special interest in terms of their synthetic chemistry, which is …
Technologies of targeting histone deacetylase in drug discovery: Current progress and emerging prospects
J Ru, Y Wang, Z Li, J Wang, C Ren, J Zhang - European Journal of …, 2023 - Elsevier
Histone deacetylases (HDACs) catalyze the hydrolysis of acetyl-l-lysine side chains in
histones and non-histones, which are key to epigenetic regulation in humans. Targeting …
histones and non-histones, which are key to epigenetic regulation in humans. Targeting …
Overview of class I HDAC modulators: Inhibitors and degraders
Z Huang, L Zeng, B Cheng, D Li - European Journal of Medicinal Chemistry, 2024 - Elsevier
Class I histone deacetylases (HDACs) are closely associated with the development of a
diverse array of diseases, including cancer, neurodegenerative disorders, HIV, and …
diverse array of diseases, including cancer, neurodegenerative disorders, HIV, and …
Contribution of Knoevenagel condensation products toward the development of anticancer agents: An updated review
R Tokala, D Bora, N Shankaraiah - ChemMedChem, 2022 - Wiley Online Library
Knoevenagel condensation is an entrenched, prevailing, prominent arsenal following
greener principles in the generation of α, β‐unsaturated ketones/carboxylic acids by …
greener principles in the generation of α, β‐unsaturated ketones/carboxylic acids by …
Synthesis and in vitro antibacterial, antifungal, anti-proliferative activities of novel adamantane-containing thiazole compounds
Abstract A series of (Z)-N-(adamantan-1-yl)-3, 4-diarylthiazol-2 (3 H)-imines (5a-r) was
synthesized via condensation of 1-(adamantan-1-yl)-3-arylthioureas (3a-c) with various aryl …
synthesized via condensation of 1-(adamantan-1-yl)-3-arylthioureas (3a-c) with various aryl …