Skeletal muscle tissue engineering: methods to form skeletal myotubes and their applications
Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate defective skeletal
muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two …
muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two …
Clinical applications of naturally derived biopolymer-based scaffolds for regenerative medicine
Naturally derived polymeric biomaterials, such as collagens, silks, elastins, alginates, and
fibrins are utilized in tissue engineering due to their biocompatibility, bioactivity, and tunable …
fibrins are utilized in tissue engineering due to their biocompatibility, bioactivity, and tunable …
Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy
S Corti, M Nizzardo, C Simone, M Falcone… - Science translational …, 2012 - science.org
Spinal muscular atrophy (SMA) is among the most common genetic neurological diseases
that cause infant mortality. Induced pluripotent stem cells (iPSCs) generated from skin …
that cause infant mortality. Induced pluripotent stem cells (iPSCs) generated from skin …
Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy
KKY Ling, RM Gibbs, Z Feng… - Human molecular …, 2012 - academic.oup.com
Spinal muscular atrophy (SMA), a motoneuron disease caused by a deficiency of the
survival of motor neuron (SMN) protein, is characterized by motoneuron loss and muscle …
survival of motor neuron (SMN) protein, is characterized by motoneuron loss and muscle …
Neuromuscular junction formation between human stem cell-derived motoneurons and human skeletal muscle in a defined system
X Guo, M Gonzalez, M Stancescu, HH Vandenburgh… - Biomaterials, 2011 - Elsevier
Functional in vitro models composed of human cells will constitute an important platform in
the next generation of system biology and drug discovery. This study reports a novel human …
the next generation of system biology and drug discovery. This study reports a novel human …
Drug treatment for spinal muscular atrophy types II and III
RI Wadman, WL van der Pol… - Cochrane Database …, 2020 - cochranelibrary.com
Background Spinal muscular atrophy (SMA) is caused by a homozygous deletion of the
survival motor neuron 1 (SMN1) gene on chromosome 5, or a heterozygous deletion in …
survival motor neuron 1 (SMN1) gene on chromosome 5, or a heterozygous deletion in …
In vitro differentiation of functional human skeletal myotubes in a defined system
In vitro human skeletal muscle systems are valuable tools for the study of human muscular
development, disease and treatment. However, published in vitro human muscle systems …
development, disease and treatment. However, published in vitro human muscle systems …
SMN in spinal muscular atrophy and snRNP biogenesis
TH Coady, CL Lorson - Wiley Interdisciplinary Reviews: RNA, 2011 - Wiley Online Library
Ribonucleoprotein (RNP) complexes function in nearly every facet of cellular activity. The
spliceosome is an essential RNP that accurately identifies introns and catalytically removes …
spliceosome is an essential RNP that accurately identifies introns and catalytically removes …
Drug treatment for spinal muscular atrophy type I
RI Wadman, WL van der Pol… - Cochrane Database …, 2019 - cochranelibrary.com
Background Spinal muscular atrophy (SMA) is caused by a homozygous deletion of the
survival motor neuron 1 (SMN1) gene on chromosome 5, or a heterozygous deletion in …
survival motor neuron 1 (SMN1) gene on chromosome 5, or a heterozygous deletion in …
Electrospun nanofibers facilitate better alignment, differentiation, and long-term culture in an in vitro model of the neuromuscular junction (NMJ)
The neuromuscular junction (NMJ) is a specialized synapse between motor neurons and the
muscle fibers they innervate. Due to the complexity of various signalling molecules and …
muscle fibers they innervate. Due to the complexity of various signalling molecules and …