Inflammasomes are multi-protein macromolecular complexes that typically comprise of three
units, a sensor, an adaptor and procaspase-1. The assembly of each inflammasome is …

Multiple sclerosis (MS) is a chronic, autoimmune and neuroinflammatory disease of the
central nervous system (CNS) mediated by autoreactive T cells directed against myelin …

Background Amongst risk alleles associated with late-onset Alzheimer's disease (AD), those
that converged on the regulation of microglia activity have emerged as central to disease …

DNA damage and type I interferons (IFNs) contribute to inflammatory responses after
traumatic brain injury (TBI). TBI-induced activation of microglia and peripherally-derived …

Currently, a combination of marijuana cannabinoids including delta-9-tetrahydrocannabinol
(THC) and cannabidiol (CBD) is used as a drug to treat muscle spasticity in patients with …

Stress is well known to contribute to the development of both neurological and psychiatric
diseases. In the central nervous system, a role for STING (stimulator of interferon genes) in …

Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system
(CNS). Interferon (IFN)-β constitutes one of the first-line therapies to treat MS, but has limited …

Stroke ranks second as a leading cause of death and permanent disability globally.
Microglia, innate immune cells in the brain, respond rapidly to ischemic injury, triggering a …

Abstract Recombinant interferon (IFN) β-1b was approved by the US Food and Drug
Administration as the first disease-modifying therapy (DMT) for multiple sclerosis (MS) in …

In recent years, the role of B cells in neurological disorders has substantially expanded our
perspectives on mechanisms of neuroinflammation. The success of B cell-depleting …