Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

A de Morree, TA Rando - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Adult stem cells are important for mammalian tissues, where they act as a cell reserve that
supports normal tissue turnover and can mount a regenerative response following acute …

Regulation of the tumor immune microenvironment by cancer-derived circular RNAs

L Guan, Q Hao, F Shi, B Gao, M Wang, X Zhou… - Cell Death & …, 2023 - nature.com
Circular RNA (circRNAs) is a covalently closed circular non-coding RNA formed by reverse
back-splicing from precursor messenger RNA. It is found widely in eukaryotic cells and can …

The SARS-CoV-2 RNA–protein interactome in infected human cells

N Schmidt, CA Lareau, H Keshishian, S Ganskih… - Nature …, 2021 - nature.com
Characterizing the interactions that SARS-CoV-2 viral RNAs make with host cell proteins
during infection can improve our understanding of viral RNA functions and the host innate …

[HTML][HTML] Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart

PK Govindappa, M Patil, VNS Garikipati… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
RNA-binding proteins like human antigen R (HuR) are key regulators in post-transcriptional
control of gene expression in several pathophysiological conditions. Diabetes adversely …

Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing

P Pararajalingam, KM Coyle, SE Arthur… - Blood, The Journal …, 2020 - ashpublications.org
Mantle cell lymphoma (MCL) is an uncommon B-cell non-Hodgkin lymphoma (NHL) that is
incurable with standard therapies. The genetic drivers of this cancer have not been firmly …

YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation

A Grenov, H Hezroni, L Lasman, JH Hanna, Z Shulman - Cell Reports, 2022 - cell.com
Antibody-mediated immunity is initiated by B cell differentiation into multiple cell subsets,
including plasmablast, memory, and germinal center (GC) cells. B cell differentiation …

RNA-binding proteins in the control of LPS-induced macrophage response

DH Ostareck, A Ostareck-Lederer - Frontiers in genetics, 2019 - frontiersin.org
Innate immune response is triggered by pathogen components, like lipopolysaccharides
(LPS) of gram-negative bacteria. LPS initiates Toll-like receptor 4 (TLR4) signaling, which …

RNA-binding protein expression alters upon differentiation of human B cells and T cells

ND Zandhuis, BP Nicolet, MC Wolkers - Frontiers in immunology, 2021 - frontiersin.org
B cells and T cells are key players in the defence against infections and malignancies. To
exert their function, B cells and T cells differentiate into effector and memory cells. Tight …

E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases

Z Wang, M Zhao, J Yin, L Liu, L Hu… - The Journal of …, 2020 - Am Soc Clin Investig
T follicular helper (Tfh) cells are indispensable for the formation of germinal center (GC)
reactions, whereas T follicular regulatory (Tfr) cells inhibit Tfh-mediated GC responses …

Modulation of miRISC-mediated gene silencing in eukaryotes

CF Jungers, S Djuranovic - Frontiers in molecular biosciences, 2022 - frontiersin.org
Gene expression is regulated at multiple levels in eukaryotic cells. Regulation at the post-
transcriptional level is modulated by various trans-acting factors that bind to specific …