Mannose receptor (MR) is a C-type lectin primarily expressed by macrophages and dendritic
cells. Its three distinct extracellular binding sites recognise a wide range of both endogenous …

To recognise and respond to pathogens, germ-line encoded pattern recognition receptors
(PRRs) bind to conserved microbial structures and activate host defence systems, including …

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pose a
significant threat to human health. Polymorphonuclear leukocytes (PMN) are the first …

Francisella tularensis is a zoonotic intracellular pathogen and the causative agent of the
debilitating febrile illness tularemia. Although natural infections by F. tularensis are sporadic …

Francisella tularensis causes systemic disease in humans and other mammals, with high
morbidity and mortality associated with inhalation-acquired infection. F. tularensis is a …

Antibody-dependent cellular cytotoxicity (ADCC) and complement fixation both appear to
play a role in mediating antitumor effects of monoclonal antibodies (mAbs), including …

The highly infectious bacterium Francisella tularensis is a facultative intracellular pathogen,
whose virulence requires proliferation inside host cells, including macrophages. Here we …

Francisella tularensis is a facultative intracellular gram-negative pathogen and the
etiological agent of the zoonotic disease tularemia. Recent advances in the field of …

Francisella tularensis is a Gram-negative intracellular pathogen and the causative agent of
the disease tularemia. Inhalation of as few as 10 bacteria is sufficient to cause severe …

The intracellular Gram-negative bacterium Francisella tularensis causes the disease
tularemia and is known for its ability to subvert host immune responses. Previous work from …