Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

Genetic mutations that affect telomerase function or telomere maintenance result in a variety
of diseases collectively called telomeropathies. This wide spectrum of disorders, which …

Human telomerase is a RNA–protein complex that extends the 3′ end of linear
chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG. Its activity is …

Background Dyskeratosis congenita (DC) is a multisystem syndrome characterized by
mucocutaneous abnormalities, bone marrow failure, and predisposition to cancer. Studies …

Dyskeratosis congenita is a rare hereditary disease that occurs predominantly in males and
manifests clinically as the classic triad of reticulate hyperpigmentation, nail dystrophy and …

Protecting telomere from the DNA damage response is essential to avoid the entry into
cellular senescence and organismal aging. The progressive telomere DNA shortening in …

Aging has emerged at the forefront of scientific research due to the growing social and
economic costs associated with the growing aging global population. The defining features …

The Shelterin complex protein TPP1 interacts with human telomerase (TERT) by means of
the TEL-patch region, controlling telomere homeostasis. Aberrations in the TPP1-TERT …

Reticulate pigmentary disorders (RPDs) are a group of inherited and acquired skin
conditions characterized by hyperpigmented and/or hypopigmented macules. Inherited …

Telomeres are nucleoprotein structures that protect the chromosome ends from degradation
and fusion. Telomerase is a ribonucleoprotein complex essential to maintain the length of …