[HTML][HTML] Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …
Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery
Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …
INFOGEST static in vitro simulation of gastrointestinal food digestion
Developing a mechanistic understanding of the impact of food structure and composition on
human health has increasingly involved simulating digestion in the upper gastrointestinal …
human health has increasingly involved simulating digestion in the upper gastrointestinal …
50 years of oral lipid-based formulations: provenance, progress and future perspectives
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …
Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos
I Maji, S Mahajan, A Sriram, P Medtiya… - Journal of Controlled …, 2021 - Elsevier
A significant proportion of recently approved drug molecules possess poor aqueous
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …
Effect of processing technologies on the digestibility of egg proteins
Egg and egg products are a rich source of highly bioavailable animal proteins. Several
processing technologies can affect the structural and functional properties of these proteins …
processing technologies can affect the structural and functional properties of these proteins …
In vitro digestion models to evaluate lipid based drug delivery systems; present status and current trends
During the past two decades, a range of in vitro models simulating the digestion processes
occurring in the stomach and small intestine have been developed to characterize lipid …
occurring in the stomach and small intestine have been developed to characterize lipid …
[HTML][HTML] Synergistic stabilization of emulsion gel by nanoparticles and surfactant enables 3D printing of lipid-rich solid oral dosage forms
J Johannesson, MM Pathare, M Johansson… - Journal of Colloid and …, 2023 - Elsevier
Pharmaceutical formulation of oral dosage forms is continuously challenged by the low
solubility of new drug candidates. Pickering emulsions, emulsions stabilized with solid …
solubility of new drug candidates. Pickering emulsions, emulsions stabilized with solid …
[HTML][HTML] In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives
Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral
absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo …
absorption of poorly water-soluble drugs. However, construction of in vitro and in vivo …
A proof of concept for 3D printing of solid lipid-based formulations of poorly water-soluble drugs to control formulation dispersion kinetics
Purpose The use of three-dimensional printing (3DP) in the development of pharmaceutical
dosage forms is growing rapidly. However, the research is almost exclusively focussed on …
dosage forms is growing rapidly. However, the research is almost exclusively focussed on …