Background & Aims Accurate estimates for the contemporary burden of chronic liver disease
(CLD) are vital for setting clinical, research, and policy priorities. We aimed to review the …

Importance The prevalence of irritable bowel syndrome (IBS) in the United States is between
7% and 16%, most common in women and young people, with annual direct costs estimated …

Background & Aims Gastrointestinal diseases account for considerable health care use and
expenditures. We estimated the annual burden, costs, and research funding associated with …

This guideline presents an update to the 2013 American College of Gastroenterology
Guideline on the Diagnosis and Management of Celiac Disease with updated …

Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders
seen by clinicians in both primary and secondary care. Since publication of the last British …

We performed systematic reviews addressing predefined clinical questions to develop
recommendations with the GRADE approach regarding management of patients with overt …

With a worldwide prevalence of 15%, chronic constipation is one of the most frequent
gastrointestinal diagnoses made in ambulatory medicine clinics, and is a common source …

Background Postoperative complications, especially pulmonary complications, affect more
than half the patients who undergo open esophagectomy for esophageal cancer. Whether …

Background & Aims Multiple environmental factors have been associated with the
development of inflammatory bowel diseases (IBDs). We performed an umbrella review of …

Background & Aims Intrahepatic cholangiocarcinoma (ICC) is the second most common liver
malignancy. ICC typically features remarkable cellular heterogeneity and a dense stromal …