Currently, obesity has become a global health issue and is referred to as an epidemic.
Dysfunctional obese adipose tissue plays a pivotal role in the development of insulin …

The important role of mitochondria in the regulation of white adipose tissue (WAT)
remodeling and energy balance is increasingly appreciated. The remarkable heterogeneity …

Background & Aims Adipose tissue dysfunction is involved in the development of insulin
resistance and is responsible for excessive lipid delivery to other organs such as the liver …

Insulin inhibits systemic nonesterified fatty acid (NEFA) flux to a greater degree than glucose
or any other metabolite. This remarkable effect is mainly due to insulin-mediated inhibition of …

Insulin resistance is one of the earliest pathological features of a suite of diseases including
type 2 diabetes collectively referred to as metabolic syndrome. There is a growing body of …

Obesity and insulin resistance (IR) are associated with endoplasmic reticulum (ER) stress
and mitochondrial dysfunction in several tissues. Although for many years mitochondrial and …

The impact of overnutrition early in life is not restricted to the onset of cardiovascular and
metabolic diseases, but also affects critical brain functions related to cognition. This study …

Aims: To investigate the impact of exogenous hydrogen sulfide (H2S) and its endogenous
biosynthesis on human adipocytes and adipose tissue in the context of obesity and insulin …

The development of many chronic diseases is associated with an excess of free radicals
leading to harmful oxidative stress. Certain probiotic strains have been shown to have …

The liver is particularly susceptible to the detrimental effects of a high-fat diet (HFD), rapidly
developing lipid accumulation and impaired cellular homeostasis. Recently, dietary nitrate …