In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

Many bacteria produce extracellular and surface-associated components such as
membrane vesicles (MVs), extracellular DNA and moonlighting cytosolic proteins for which …

Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

Antibiotic resistance continues to hamper antimicrobial chemotherapy of infectious disease,
and while biocide resistance outside of the laboratory is as yet unrealized, in vitro and in …

Synthetic biology aims to systematically design and construct novel biological systems that
address energy, environment, and health issues. Herein, we describe the development of a …

Pseudomonas aeruginosa strains exhibit significant variability in pathogenicity and
ecological flexibility. Such interstrain differences reflect the dynamic nature of the P …

Chronic respiratory diseases including chronic rhinosinusitis, otitis media, asthma, cystic
fibrosis, non-CF bronchiectasis, and chronic obstructive pulmonary disease are a major …

Over the past two decades, researchers studying both microbial and host cell communities
have gained an appreciation for the ability of bacteria to produce, regulate, and functionally …