Compounds incorporating guanidine moieties constitute a versatile class of biologically
interesting molecules with a wide array of applications. As such, guanidines have been …

Guanidines are fascinating small nitrogen-rich organic compounds, which have been
frequently associated with a wide range of biological activities. This is mainly due to their …

From organosuperbases capable of base-catalyzing organic reactions, through versatile
'ligand-sets' for use in coordination chemistry, to fundamental entities in medicinal chemistry …

Multisubstituted guanidines have received much attention because of important applications
in many fields, such as pharmaceutics, organometallic and coordination chemistry, and …

Salification of new drug substances in order to improve physico-chemical or solid-state
properties (eg dissolution rate or solubility, appropriate workup process, storage for further …

We report the generation and statistical analysis of the CSD drug subset: a subset of the
Cambridge Structural Database (CSD) consisting of every published small-molecule crystal …

Hydrogen-bonding promoted covalent modifications are finding useful applications in small-
molecule chemical synthesis and detection. We have designed a xanthene-based …

Guanidinium-rich scaffolds facilitate cellular translocation and delivery of bioactive cargos
through biological barriers. Although impressive uptake has been demonstrated for …

Redox-active guanidines are ideal proton-coupled electron-transfer (PCET) reagents, since
they combine a high Brønsted basicity with a low and tunable redox potential. In this article …

Conspectus Molecular compounds, organic and inorganic, crystallize in diverse and
complex structures. They continue to inspire synthetic efforts and “crystal engineering”, with …