Cognitive decline covers a broad spectrum of disorders, not only resulting from brain
diseases but also from systemic diseases, which seriously influence the quality of life and …

Emerging evidence suggests that vascular pathological changes play a pivotal role in the
pathogenesis of Alzheimer's disease (AD). The dysfunction of the cerebral vasculature …

In this review, we first describe the current understanding of glial-mediated vascular function
affecting the role of the blood-brain barrier (BBB) in central nervous system (CNS) disorders …

The term neuronutrition has been proposed as part of nutritional neuroscience, studying the
effects of various dietary components on behavior and cognition. Other researchers …

Celecoxib (CXB), a selective COX-2 inhibitor, is a component of triple-oral-metronomic-
chemotherapy. However, chronic CXB utilization in high doses could bring about major …

The obstruction of blood–brain barrier (BBB) and the poor specific targeting are still the
major obstacles and challenges of targeted nano-pharmaceutical therapy for glioblastoma …

Aims Transactivation of insulin-growth-factor-receptor (IGF-1R) by angiotensin-II-type-1-
receptor (AT-1R) was only demonstrated in vascular-smooth-muscle cells and has never …

To date, liver fibrosis has no clinically approved treatment. Empagliflozin (EMPA), a highly
selective sodium-glucose-cotransporter-2 (SGLT2) inhibitor, has shown ameliorative …

In this study, 50 SD adult male mice were used to create an Alzheimer's disease model. The
mice's learning and memory abilities were evaluated using an eight-arm radial maze …

Introduction A recent approach to cure neurodegenerative diseases is to reprogram
fibroblasts into functioning neurons using multiple exogenous transcription factors (TFs) and …