Genetics of substance use disorders in the era of big data
J Gelernter, R Polimanti - Nature Reviews Genetics, 2021 - nature.com
Substance use disorders (SUDs) are conditions in which the use of legal or illegal
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
substances, such as nicotine, alcohol or opioids, results in clinical and functional …
The “alcoholic other”: Harmful drinkers resist problem recognition to manage identity threat
Objective Harmful drinkers represent an important Alcohol Use Disorder (AUD) group in
public health terms, accounting for significant health and social costs. However, harmful …
public health terms, accounting for significant health and social costs. However, harmful …
Continuum beliefs are associated with higher problem recognition than binary beliefs among harmful drinkers without addiction experience
Low problem recognition may be an important barrier to opportunities for self-change or help-
seeking in harmful drinkers. Little is known about how the beliefs harmful drinkers hold …
seeking in harmful drinkers. Little is known about how the beliefs harmful drinkers hold …
[HTML][HTML] Alcohol sensitivity as an endophenotype of alcohol use disorder: Exploring its translational utility between rodents and humans
CC Parker, R Lusk, LM Saba - Brain Sciences, 2020 - mdpi.com
Alcohol use disorder (AUD) is a complex, chronic, relapsing disorder with multiple
interacting genetic and environmental influences. Numerous studies have verified the …
interacting genetic and environmental influences. Numerous studies have verified the …
Evaluating risk for alcohol use disorder: Polygenic risk scores and family history
Background Early identification of individuals at high risk for alcohol use disorder (AUD)
coupled with prompt interventions could reduce the incidence of AUD. In this study, we …
coupled with prompt interventions could reduce the incidence of AUD. In this study, we …
[HTML][HTML] Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach
Alcohol use (ie, quantity, frequency) and alcohol use disorder (AUD) are common,
associated with adverse outcomes, and genetically-influenced. Genome-wide association …
associated with adverse outcomes, and genetically-influenced. Genome-wide association …
Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach
Abstract Purpose Posttraumatic Stress Disorder (PTSD) is associated with increased alcohol
use and alcohol use disorder (AUD), which are all moderately heritable. Studies suggest the …
use and alcohol use disorder (AUD), which are all moderately heritable. Studies suggest the …
Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples
Background Studies suggest that alcohol consumption and alcohol use disorders have
distinct genetic backgrounds. Methods We examined whether polygenic risk scores (PRS) …
distinct genetic backgrounds. Methods We examined whether polygenic risk scores (PRS) …
Genome‐wide association studies of the self‐rating of effects of ethanol (SRE)
The level of response (LR) to alcohol as measured with the Self‐Report of the Effects of
Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually …
Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually …
Polygenic risk score for problematic alcohol use predicts heavy drinking and alcohol use disorder symptoms in young adulthood after accounting for adolescent …
Background Genome-wide association studies (GWAS) have identified hundreds of loci
associated with alcohol-related traits. GWAS permit the calculation of polygenic risk scores …
associated with alcohol-related traits. GWAS permit the calculation of polygenic risk scores …