GPR114/ADGRG5 is activated by its tethered peptide agonist because it is a cleaved adhesion GPCR
TF Bernadyn, A Vizurraga, R Adhikari… - Journal of Biological …, 2023 - ASBMB
Family B2 or adhesion G protein–coupled receptors (AGPCRs) are distinguished by variable
extracellular regions that contain a modular protease, termed the GPCR autoproteolysis …
extracellular regions that contain a modular protease, termed the GPCR autoproteolysis …
Targeting adhesion G protein-coupled receptors. Current status and future perspectives
G protein-coupled receptors (GPCRs) orchestrate many physiological functions and are a
crucial target in drug discovery. Adhesion GPCRs (aGPCRs), the second largest family …
crucial target in drug discovery. Adhesion GPCRs (aGPCRs), the second largest family …
GPR56/ADGRG1 induces biased Rho-ROCK-MLC and JAK-STAT3 signaling to promote amoeboid-like morphology and IL-6 upregulation in melanoma cells
KY Huang, KF Ng, I Kuan-Yu, YC Chang, HY Chen… - 2024 - researchsquare.com
Background GPR56/ADGRG1 is an adhesion G protein-coupled receptor that plays a role in
cell-matrix interaction and metastasis of human melanoma cells. We have shown previously …
cell-matrix interaction and metastasis of human melanoma cells. We have shown previously …