Old trade, new tricks: insights into the spontaneous mutation process from the partnering of classical mutation accumulation experiments with high-throughput …
V Katju, U Bergthorsson - Genome Biology and Evolution, 2019 - academic.oup.com
Mutations spawn genetic variation which, in turn, fuels evolution. Hence, experimental
investigations into the rate and fitness effects of spontaneous mutations are central to the …
investigations into the rate and fitness effects of spontaneous mutations are central to the …
Precise estimates of mutation rate and spectrum in yeast
Mutation is the ultimate source of genetic variation. The most direct and unbiased method of
studying spontaneous mutations is via mutation accumulation (MA) lines. Until recently, MA …
studying spontaneous mutations is via mutation accumulation (MA) lines. Until recently, MA …
Bet hedging in yeast by heterogeneous, age-correlated expression of a stress protectant
Genetically identical cells grown in the same culture display striking cell-to-cell
heterogeneity in gene expression and other traits. A crucial challenge is to understand how …
heterogeneity in gene expression and other traits. A crucial challenge is to understand how …
Whole genome, whole population sequencing reveals that loss of signaling networks is the major adaptive strategy in a constant environment
DJ Kvitek, G Sherlock - PLoS genetics, 2013 - journals.plos.org
Molecular signaling networks are ubiquitous across life and likely evolved to allow
organisms to sense and respond to environmental change in dynamic environments. Few …
organisms to sense and respond to environmental change in dynamic environments. Few …
Decanalizing thinking on genetic canalization
K Geiler-Samerotte, FMO Sartori, ML Siegal - Seminars in cell & …, 2019 - Elsevier
The concept of genetic canalization has had an abiding influence on views of complex-trait
evolution. A genetically canalized system has evolved to become less sensitive to the effects …
evolution. A genetically canalized system has evolved to become less sensitive to the effects …
Neural networks enable efficient and accurate simulation-based inference of evolutionary parameters from adaptation dynamics
The rate of adaptive evolution depends on the rate at which beneficial mutations are
introduced into a population and the fitness effects of those mutations. The rate of beneficial …
introduced into a population and the fitness effects of those mutations. The rate of beneficial …
Prochlorococcus have low global mutation rate and small effective population size
Prochlorococcus are the most abundant free-living photosynthetic carbon-fixing organisms
in the ocean. Prochlorococcus show small genome sizes, low genomic G+ C content …
in the ocean. Prochlorococcus show small genome sizes, low genomic G+ C content …
Extraordinary genome stability in the ciliate Paramecium tetraurelia
Mutation plays a central role in all evolutionary processes and is also the basis of genetic
disorders. Established base-substitution mutation rates in eukaryotes range between∼ 5× …
disorders. Established base-substitution mutation rates in eukaryotes range between∼ 5× …
High-throughput identification of adaptive mutations in experimentally evolved yeast populations
High-throughput sequencing has enabled genetic screens that can rapidly identify mutations
that occur during experimental evolution. The presence of a mutation in an evolved lineage …
that occur during experimental evolution. The presence of a mutation in an evolved lineage …
Selection transforms the landscape of genetic variation interacting with Hsp90
The protein-folding chaperone Hsp90 has been proposed to buffer the phenotypic effects of
mutations. The potential for Hsp90 and other putative buffers to increase robustness to …
mutations. The potential for Hsp90 and other putative buffers to increase robustness to …