The community-function landscape of microbial consortia

A Sanchez, D Bajic, J Diaz-Colunga, A Skwara… - Cell Systems, 2023 - cell.com
Quantitatively linking the composition and function of microbial communities is a major
aspiration of microbial ecology. Microbial community functions emerge from a complex web …

Statistically learning the functional landscape of microbial communities

A Skwara, K Gowda, M Yousef… - Nature ecology & …, 2023 - nature.com
Microbial consortia exhibit complex functional properties in contexts ranging from soils to
bioreactors to human hosts. Understanding how community composition determines …

More than the sum of its parts: uncovering emerging effects of microbial interactions in complex communities

P Geesink, J Ter Horst… - FEMS Microbiology …, 2024 - academic.oup.com
Microbial communities are not only shaped by the diversity of microorganisms and their
individual metabolic potential, but also by the vast amount of intra-and interspecies …

Predictability of the community‐function landscape in wine yeast ecosystems

J Ruiz, M de Celis, J Diaz‐Colunga… - Molecular Systems …, 2023 - embopress.org
Predictively linking taxonomic composition and quantitative ecosystem functions is a major
aspiration in microbial ecology, which must be resolved if we wish to engineer microbial …

Artificial selection improves pollutant degradation by bacterial communities

FI Arias-Sánchez, B Vessman, A Haym… - Nature …, 2024 - nature.com
Artificial selection is a promising way to improve microbial community functions, but previous
experiments have only shown moderate success. Here, we experimentally evaluate a new …

Learning beyond-pairwise interactions enables the bottom–up prediction of microbial community structure

H Ishizawa, Y Tashiro, D Inoue… - Proceedings of the …, 2024 - National Acad Sciences
Understanding the assembly of multispecies microbial communities represents a significant
challenge in ecology and has wide applications in agriculture, wastewater treatment, and …

Environmental memory alters the fitness effects of adaptive mutations in fluctuating environments

CI Abreu, S Mathur, DA Petrov - Nature Ecology & Evolution, 2024 - nature.com
Evolution in a static laboratory environment often proceeds via large-effect beneficial
mutations that may become maladaptive in other environments. Conversely, natural settings …

Bacteroides acidifaciens: Linking dietary fiber to liver health

VA Petrov, CC Laczny, P Wilmes - Cell Metabolism, 2024 - cell.com
While innumerous associative microbiome studies have been published, mechanistic links
between the microbiome and host physiology remain much scarcer. In Cell Host & Microbe …

Epistasis and pleiotropy shape biophysical protein subspaces associated with drug resistance

CB Ogbunugafor, RF Guerrero, MD Miller-Dickson… - Physical Review E, 2023 - APS
Protein space is a rich analogy for genotype-phenotype maps, where amino acid sequence
is organized into a high-dimensional space that highlights the connectivity between protein …

Toward a fundamental theory of taxon transitions in microbial communities

CB Ogbunugafor, S Yitbarek - Proceedings of the National …, 2024 - National Acad Sciences
Technological breakthroughs have fostered an appreciation for the microbiome and
revolutionized our understanding of many parts of the tree of life. These discoveries have …