The B cell receptor (BCR) pathway has been identified as a potential therapeutic target in a
number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse …

Aberrant B cell signaling plays a critical in role in various systemic and organ-specific
autoimmune diseases. This is supported by genetic evidence by many functional studies in …

Anergic T cells have altered diacylglycerol metabolism, but whether that altered metabolism
has a causative function in the induction of T cell anergy is not apparent. To test the …

Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection.
Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining …

Excessive bone loss in arthritic diseases is mostly due to abnormal activation of the immune
system leading to stimulation of osteoclasts. While phospholipase Cγ (PLCγ) isoforms are …

P2X7 receptor, a purinergic receptor family member, is abundantly expressed on many cells,
including immune, muscle, bone, neuron, and glia. It acts as an ATP-activated cation …

Stem cell factor (SCF) acts in synergy with antigen to enhance the calcium signal,
degranulation, activation of transcription factors, and cytokine production in human mast …

Systemic lupus erythematosus (SLE) is a progressive autoimmune disease characterized by
increased sensitivity to self-antigens, auto-antibody production, and systemic inflammation …

Abstract Objective Rates of IgE‐mediated food allergy (FA) have increased over the last few
decades, and mounting evidence implicates disruption of epigenetic profiles in various …

A series of signal-directed transitions regulates the development of distinct populations of
self-tolerant B cells and ultimately the production of antibody-producing plasma cells. We …