The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …

Mammalian models including non‐human primates, pigs and rodents have been used
extensively to study the mechanisms of cardiovascular disease. However, there is an …

Neurovascular coupling (NVC), which mediates rapid increases in cerebral blood flow in
response to neuronal activation, is commonly used to map brain activation or dysfunction …

Food intake and energy expenditure are sensed and processed by multiple brain centres to
uphold energy homeostasis. Evidence from the past decade points to the brain vasculature …

Numerous epidemiological and preclinical studies have established a strong correlation
between type 2 diabetes (T2DM) and cognitive impairment and T2DM is now established as …

The task of blood vessel segmentation in microscopy images is crucial for many diagnostic
and research applications. However, vessels can look vastly different, depending on the …

Zebrafish transgenic lines and light sheet fluorescence microscopy allow in-depth insights
into three-dimensional vascular development in vivo. However, quantification of the …

Zebrafish has become a popular model to study many physiological and pathophysiological
processes in humans. In recent years, it has rapidly emerged in the study of metabolic …

Type 2 diabetes causes substantial long-term damage in several organs including the brain.
Cognitive decline is receiving increased attention as diabetes has been established as an …

Blood flow in the retina increases in response to light-evoked neuronal activity, ensuring that
retinal neurons receive an adequate supply of oxygen and nutrients as metabolic demands …