[HTML][HTML] The diverse functionality of NQO1 and its roles in redox control

D Ross, D Siegel - Redox Biology, 2021 - Elsevier
In this review, we summarize the multiple functions of NQO1, its established roles in redox
processes and potential roles in redox control that are currently emerging. NQO1 has …

NAD (P) H: quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

AT Dinkova-Kostova, P Talalay - Archives of biochemistry and biophysics, 2010 - Elsevier
NAD (P) H: quinone acceptor oxidoreductase 1 (NQO1) is a widely-distributed FAD-
dependent flavoprotein that promotes obligatory 2-electron reductions of quinones …

[HTML][HTML] Metabolism and function of coenzyme Q

M Turunen, J Olsson, G Dallner - Biochimica et Biophysica Acta (BBA) …, 2004 - Elsevier
Coenzyme Q (CoQ) is present in all cells and membranes and in addition to be a member of
the mitochondrial respiratory chain it has also several other functions of great importance for …

The Nrf2 system as a potential target for the development of indirect antioxidants

KA Jung, MK Kwak - Molecules, 2010 - mdpi.com
Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

AT Dinkova‐Kostova, P Talalay - Molecular nutrition & food …, 2008 - Wiley Online Library
Cellular protection against oxidative and electrophile toxicities is provided by two types of
small‐molecule antioxidants:(i) direct antioxidants, which are redox active, short‐lived, are …

Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects

RT Matthews, L Yang, S Browne… - Proceedings of the …, 1998 - National Acad Sciences
Coenzyme Q10 is an essential cofactor of the electron transport chain as well as a potent
free radical scavenger in lipid and mitochondrial membranes. Feeding with coenzyme Q10 …

NAD (P) H: quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms

D Ross, JK Kepa, SL Winski, HD Beall, A Anwar… - Chemico-biological …, 2000 - Elsevier
NAD (P) H: quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is
involved in chemoprotection and can also bioactivate certain antitumor quinones. This …

Chromate-Reducing Properties of Soluble Flavoproteins from Pseudomonas putida and Escherichia coli

DF Ackerley, CF Gonzalez, CH Park… - Applied and …, 2004 - Am Soc Microbiol
ABSTRACT Cr (VI)(chromate) is a toxic, soluble environmental contaminant. Bacteria can
reduce chromate to the insoluble and less toxic Cr (III), and thus chromate bioremediation is …

Contribution of NAD (P) H: quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the …

P Nioi, JD Hayes - … Research/Fundamental and Molecular Mechanisms of …, 2004 - Elsevier
NAD (P) H: quinone oxidoreductase 1 (NQO1) is a key enzyme involved in defence against
reactive forms of oxygen and inhibition of neoplasia. Under conditions of oxidative stress …

Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease

LM Aleksunes, JE Manautou - Toxicologic pathology, 2007 - journals.sagepub.com
Transcription factor NF-E2-related factor 2 (Nrf2) belongs to the basic region-leucine zipper
family and is activated in response to electrophiles and reactive oxygen species. Nrf2 …