• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Athletes epitomize the healthiest segment of society. Despite this premise, sudden cardiac
death may occur in apparently healthy athletes, attracting significant attention not only in the …

Importance Whether vigorous intensity exercise is associated with an increase in risk of
ventricular arrhythmias in individuals with hypertrophic cardiomyopathy (HCM) is unknown …

Background Causes and precipitating factors of sudden cardiac death (SCD) in adolescents
are poorly understood. Objectives The authors sought to investigate the etiologies of SCD …

Aims To describe the proportion of patients with syncope among those affected by
hypertrophic cardiomyopathy (HCM) and the relevance of syncope as risk factor for sudden …

Youth and adult participation in sports continues to increase, and athletes may be
diagnosed with potentially arrhythmogenic cardiac conditions. This international …

As explored throughout this JACC Focus Seminar series, participation in regular exercise
offers significant positive benefits for cardiovascular health. However, patients with …

Hypertrophic cardiomyopathy (HCM) is the most frequently cited cause of exercise-related
sudden cardiac death (SCD) in young individuals and has claimed the lives of some high …

The detailed physiological consequences of aerobic training, in patients with hypertrophic
cardiomyopathy (HCM), are not well understood. In athletes and nonathletes with HCM …

Background Clinical practice recommendations for participation in sports and exercise
among young competitive athletes with cardiovascular conditions at risk for sudden death …