[HTML][HTML] CRISPR-based technologies for the manipulation of eukaryotic genomes

AC Komor, AH Badran, DR Liu - Cell, 2017 - cell.com
The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …

Issues in long-term protein delivery using biodegradable microparticles

M Ye, S Kim, K Park - Journal of Controlled Release, 2010 - Elsevier
Recently, a variety of bioactive protein drugs have been available in large quantities as a
result of advances in biotechnology. Such availability has prompted development of long …

Ultrarapid‐Acting Microneedles for Immediate Delivery of Biotherapeutics

J You, C Yang, J Han, H Wang, W Zhang… - Advanced …, 2023 - Wiley Online Library
Subcutaneous (SC) injection is a common administration route for rapid and efficient
delivery of biotherapeutics. However, syringe‐based injections usually require professional …

Micro/nano encapsulation via electrified coaxial liquid jets

IG Loscertales, A Barrero, I Guerrero, R Cortijo… - Science, 2002 - science.org
We report a method to generate steady coaxial jets of immiscible liquids with diameters in
the range of micrometer/nanometer size. This compound jet is generated by the action of …

Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration

J Bonadio, E Smiley, P Patil, S Goldstein - Nature medicine, 1999 - nature.com
The inability to deliver growth factors locally in a transient but sustained manner is a
substantial barrier to tissue regeneration. Systems capable of localized plasmid gene …

Biodegradable poly (lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens

W Jiang, RK Gupta, MC Deshpande… - Advanced drug delivery …, 2005 - Elsevier
Injectable biodegradable polymeric particles (usually microspheres) represent an exciting
approach to control the release of vaccine antigens to reduce the number of doses in the …

Polyanhydride degradation and erosion

A Göpferich, J Teßmar - Advanced drug delivery reviews, 2002 - Elsevier
It was the intention of this paper to give a survey on the degradation and erosion of
polyanhydrides. Due to the multitude of polymers that have been synthesized in this class of …

Formulation aspects of biodegradable polymeric microspheres for antigen delivery

H Tamber, P Johansen, HP Merkle, B Gander - Advanced drug delivery …, 2005 - Elsevier
Biodegradable microspheres (MS) have proven to be very useful antigen delivery systems
that are ingested by immunocompetent cells and provide prolonged antigen release and …

[图书][B] Pharmaceutical inhalation aerosol technology

AJ Hickey - 2003 - taylorfrancis.com
This thoroughly revised and expanded reference provides authoritative discussions on the
physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors …

Biopolymer stereocomplexes

J Slager, AJ Domb - Advanced drug delivery reviews, 2003 - Elsevier
A polymer stereocomplex is defined as a stereoselective interaction between two
complementing stereoregular polymers, that interlock and form a new composite …