[HTML][HTML] CRISPR-based technologies for the manipulation of eukaryotic genomes
The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …
advances in the life sciences that have grown from the ability to edit genomes within living …
Issues in long-term protein delivery using biodegradable microparticles
M Ye, S Kim, K Park - Journal of Controlled Release, 2010 - Elsevier
Recently, a variety of bioactive protein drugs have been available in large quantities as a
result of advances in biotechnology. Such availability has prompted development of long …
result of advances in biotechnology. Such availability has prompted development of long …
Ultrarapid‐Acting Microneedles for Immediate Delivery of Biotherapeutics
J You, C Yang, J Han, H Wang, W Zhang… - Advanced …, 2023 - Wiley Online Library
Subcutaneous (SC) injection is a common administration route for rapid and efficient
delivery of biotherapeutics. However, syringe‐based injections usually require professional …
delivery of biotherapeutics. However, syringe‐based injections usually require professional …
Micro/nano encapsulation via electrified coaxial liquid jets
IG Loscertales, A Barrero, I Guerrero, R Cortijo… - Science, 2002 - science.org
We report a method to generate steady coaxial jets of immiscible liquids with diameters in
the range of micrometer/nanometer size. This compound jet is generated by the action of …
the range of micrometer/nanometer size. This compound jet is generated by the action of …
Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration
J Bonadio, E Smiley, P Patil, S Goldstein - Nature medicine, 1999 - nature.com
The inability to deliver growth factors locally in a transient but sustained manner is a
substantial barrier to tissue regeneration. Systems capable of localized plasmid gene …
substantial barrier to tissue regeneration. Systems capable of localized plasmid gene …
Biodegradable poly (lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens
Injectable biodegradable polymeric particles (usually microspheres) represent an exciting
approach to control the release of vaccine antigens to reduce the number of doses in the …
approach to control the release of vaccine antigens to reduce the number of doses in the …
Polyanhydride degradation and erosion
A Göpferich, J Teßmar - Advanced drug delivery reviews, 2002 - Elsevier
It was the intention of this paper to give a survey on the degradation and erosion of
polyanhydrides. Due to the multitude of polymers that have been synthesized in this class of …
polyanhydrides. Due to the multitude of polymers that have been synthesized in this class of …
Formulation aspects of biodegradable polymeric microspheres for antigen delivery
Biodegradable microspheres (MS) have proven to be very useful antigen delivery systems
that are ingested by immunocompetent cells and provide prolonged antigen release and …
that are ingested by immunocompetent cells and provide prolonged antigen release and …
[图书][B] Pharmaceutical inhalation aerosol technology
AJ Hickey - 2003 - taylorfrancis.com
This thoroughly revised and expanded reference provides authoritative discussions on the
physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors …
physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors …
Biopolymer stereocomplexes
J Slager, AJ Domb - Advanced drug delivery reviews, 2003 - Elsevier
A polymer stereocomplex is defined as a stereoselective interaction between two
complementing stereoregular polymers, that interlock and form a new composite …
complementing stereoregular polymers, that interlock and form a new composite …