The statistical mechanics of dynamic pathways to self-assembly

S Whitelam, RL Jack - Annual review of physical chemistry, 2015 - annualreviews.org
This review describes some important physical characteristics of the pathways (ie,
dynamical processes) by which molecular, nanoscale, and micrometer-scale self-assembly …

How crystals form: A theory of nucleation pathways

JF Lutsko - Science advances, 2019 - science.org
Recent advances in classical density functional theory are combined with stochastic process
theory and rare event techniques to formulate a theoretical description of nucleation …

Molecular nucleation mechanisms and control strategies for crystal polymorph selection

AES Van Driessche, N Van Gerven, PHH Bomans… - Nature, 2018 - nature.com
The formation of condensed (compacted) protein phases is associated with a wide range of
human disorders, such as eye cataracts, amyotrophic lateral sclerosis, sickle cell anaemia …

Nucleation of metastable aragonite CaCO3 in seawater

W Sun, S Jayaraman, W Chen… - Proceedings of the …, 2015 - National Acad Sciences
Predicting the conditions in which a compound adopts a metastable structure when it
crystallizes out of solution is an unsolved and fundamental problem in materials synthesis …

Nonclassical nucleation pathways in protein crystallization

F Zhang - Journal of Physics: Condensed Matter, 2017 - iopscience.iop.org
Classical nucleation theory (CNT), which was established about 90 years ago, has been
very successful in many research fields, and continues to be the most commonly used theory …

Ritonavir Form III: A new polymorph after 24 years

X Yao, RF Henry, GGZ Zhang - Journal of pharmaceutical sciences, 2023 - Elsevier
Polymorphism occurs widely in pharmaceutical solids, and must be thoroughly studied
during product development. Twenty-four years after ritonavir (RTV) Form II materialized, we …

Observing classical nucleation theory at work by monitoring phase transitions with molecular precision

M Sleutel, J Lutsko, AES Van Driessche… - Nature …, 2014 - nature.com
It is widely accepted that many phase transitions do not follow nucleation pathways as
envisaged by the classical nucleation theory. Many substances can traverse intermediate …

Ostwald Rule of Stages─ Myth or Reality?

PT Cardew - Crystal Growth & Design, 2023 - ACS Publications
In 1897, following a number of crystallization studies, Ostwald suggested that if a system has
a number of metastable states open to it then it proceeds sequentially by means of the …

Classical nucleation theory approach to two-step nucleation of crystals

D Kashchiev - Journal of Crystal Growth, 2020 - Elsevier
Crystals may not always nucleate directly in the supersaturated old phase, but rather in a
precursory metastable phase. This so-called two-step (2S) nucleation of crystals has …

A dynamical theory of nucleation for colloids and macromolecules

JF Lutsko - The Journal of chemical physics, 2012 - pubs.aip.org
A general theory of nucleation for colloids and macromolecules in solution is formulated
within the context of fluctuating hydrodynamics. A formalism for the determination of …