Whole-genome doubling in tissues and tumors
MA Vittoria, RJ Quinton, NJ Ganem - Trends in Genetics, 2023 - cell.com
The overwhelming majority of proliferating somatic human cells are diploid, and this
genomic state is typically maintained across successive cell divisions. However, failures in …
genomic state is typically maintained across successive cell divisions. However, failures in …
Translating genomic advances into biodiversity conservation
CJ Hogg - Nature Reviews Genetics, 2024 - nature.com
A key action of the new Global Biodiversity Framework is the maintenance of genetic
diversity in all species to safeguard their adaptive potential. To achieve this goal, a …
diversity in all species to safeguard their adaptive potential. To achieve this goal, a …
Centuries of genome instability and evolution in soft-shell clam, Mya arenaria, bivalve transmissible neoplasia
SFM Hart, MA Yonemitsu, RM Giersch, FES Garrett… - Nature Cancer, 2023 - nature.com
Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living
past the death of the founder animal in which the cancer initiated. We investigated the …
past the death of the founder animal in which the cancer initiated. We investigated the …
Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule
Transmissible cancers are malignant cell lineages that spread clonally between individuals.
Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like …
Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like …
Historical RNA expression profiles from the extinct Tasmanian tiger
Paleogenomics continues to yield valuable insights into the evolution, population dynamics,
and ecology of our ancestors and other extinct species. However, DNA sequencing cannot …
and ecology of our ancestors and other extinct species. However, DNA sequencing cannot …
Disease-driven top predator decline affects mesopredator population genomic structure
MA Beer, KM Proft, A Veillet, CP Kozakiewicz… - Nature Ecology & …, 2024 - nature.com
Top predator declines are pervasive and often have dramatic effects on ecological
communities via changes in food web dynamics, but their evolutionary consequences are …
communities via changes in food web dynamics, but their evolutionary consequences are …
Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial
Ninu (greater bilby, Macrotis lagotis) are desert-dwelling, culturally and ecologically
important marsupials. In collaboration with Indigenous rangers and conservation managers …
important marsupials. In collaboration with Indigenous rangers and conservation managers …
Comparative genomics of monotremes provides insights into the early evolution of mammalian epidermal differentiation genes
J Steinbinder, AP Sachslehner, KB Holthaus… - Scientific Reports, 2024 - nature.com
The function of the skin as a barrier against the environment depends on the differentiation
of epidermal keratinocytes into highly resilient corneocytes that form the outermost skin …
of epidermal keratinocytes into highly resilient corneocytes that form the outermost skin …
Cancerogenic parasites in veterinary medicine: a narrative literature review
N Fonti, F Parisi, F Mancianti, G Freer, A Poli - Infectious Agents and …, 2023 - Springer
Parasite infection is one of the many environmental factors that can significantly contribute to
carcinogenesis and is already known to be associated with a variety of malignancies in both …
carcinogenesis and is already known to be associated with a variety of malignancies in both …
Comparative genomics of the T cell receptor μ locus in marsupials and monotremes
T cells are a primary component of the vertebrate adaptive immune system. There are three
mammalian T cell lineages based on their T cell receptors (TCR). The αβ T cells and γδ T …
mammalian T cell lineages based on their T cell receptors (TCR). The αβ T cells and γδ T …