Whole-genome doubling in tissues and tumors

MA Vittoria, RJ Quinton, NJ Ganem - Trends in Genetics, 2023 - cell.com
The overwhelming majority of proliferating somatic human cells are diploid, and this
genomic state is typically maintained across successive cell divisions. However, failures in …

Translating genomic advances into biodiversity conservation

CJ Hogg - Nature Reviews Genetics, 2024 - nature.com
A key action of the new Global Biodiversity Framework is the maintenance of genetic
diversity in all species to safeguard their adaptive potential. To achieve this goal, a …

Centuries of genome instability and evolution in soft-shell clam, Myaarenaria, bivalve transmissible neoplasia

SFM Hart, MA Yonemitsu, RM Giersch, FES Garrett… - Nature Cancer, 2023 - nature.com
Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living
past the death of the founder animal in which the cancer initiated. We investigated the …

Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule

AL Bruzos, M Santamarina, D Garcia-Souto, S Díaz… - Nature Cancer, 2023 - nature.com
Transmissible cancers are malignant cell lineages that spread clonally between individuals.
Several such cancers, termed bivalve transmissible neoplasia (BTN), induce leukemia-like …

Historical RNA expression profiles from the extinct Tasmanian tiger

E Mármol-Sánchez, B Fromm, N Oskolkov… - Genome …, 2023 - genome.cshlp.org
Paleogenomics continues to yield valuable insights into the evolution, population dynamics,
and ecology of our ancestors and other extinct species. However, DNA sequencing cannot …

Disease-driven top predator decline affects mesopredator population genomic structure

MA Beer, KM Proft, A Veillet, CP Kozakiewicz… - Nature Ecology & …, 2024 - nature.com
Top predator declines are pervasive and often have dramatic effects on ecological
communities via changes in food web dynamics, but their evolutionary consequences are …

Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial

CJ Hogg, RJ Edwards, KA Farquharson… - Nature ecology & …, 2024 - nature.com
Ninu (greater bilby, Macrotis lagotis) are desert-dwelling, culturally and ecologically
important marsupials. In collaboration with Indigenous rangers and conservation managers …

Comparative genomics of monotremes provides insights into the early evolution of mammalian epidermal differentiation genes

J Steinbinder, AP Sachslehner, KB Holthaus… - Scientific Reports, 2024 - nature.com
The function of the skin as a barrier against the environment depends on the differentiation
of epidermal keratinocytes into highly resilient corneocytes that form the outermost skin …

Cancerogenic parasites in veterinary medicine: a narrative literature review

N Fonti, F Parisi, F Mancianti, G Freer, A Poli - Infectious Agents and …, 2023 - Springer
Parasite infection is one of the many environmental factors that can significantly contribute to
carcinogenesis and is already known to be associated with a variety of malignancies in both …

Comparative genomics of the T cell receptor μ locus in marsupials and monotremes

KA Morrissey, MR Stammnitz, E Murchison, RD Miller - Immunogenetics, 2023 - Springer
T cells are a primary component of the vertebrate adaptive immune system. There are three
mammalian T cell lineages based on their T cell receptors (TCR). The αβ T cells and γδ T …