Cell proliferation and differentiation show a remarkable inverse relationship. Precursor cells
continue division before acquiring a fully differentiated state, while terminal differentiation …

Activation of Mechanistic target of rapamycin (mTOR) signaling plays a crucial role in
tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical …

The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of
approximately 15 months. Current preclinical GBM models are limited by the lack of a" …

The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained
exclusively by a rare fraction of cells with stem cell properties,. Although the existence of …

Abstract Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are
involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose …

A causative understanding of genetic factors that regulate glioblastoma pathogenesis is of
central importance. Here we developed an adeno-associated virus–mediated …

WNTs and their downstream effectors regulate proliferation, death, and migration and cell
fate decision. Deregulation of WNT signaling is associated with various cancers including …

Glioblastoma (GBM) is the most common malignant primary brain tumor of adults and one of
the most lethal of all cancers. Epidermal growth factor receptor (EGFR) mutations (EGFRvIII) …

A defining hallmark of glioblastoma is altered tumor metabolism. The metabolic shift towards
aerobic glycolysis with reprogramming of mitochondrial oxidative phosphorylation …

FoxO Forkhead transcription factors are shown here to act as signal transducers at the
confluence of Smad, PI3K, and FoxG1 pathways. Smad proteins activated by TGF-β form a …