Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

Reduced oxygen levels (hypoxia) is one of the most important factors influencing clinical
outcome after radiotherapy. This is primarily because hypoxic cells are resistant to radiation …

Tumor hypoxia is a well-established biological phenomenon that affects the curability of
solid tumors, regardless of treatment modality. Especially for head and neck cancer patients …

Positron emission tomography (PET) is a powerful and rapidly developing area of molecular
imaging that is used to study and visualize human physiology by the detection of positron …

Oxygen is required to sustain aerobic organisms. Reactive oxygen species (ROS) are
constantly released during mitochondrial oxygen consumption for energy production. Any …

PURPOSE: Hypoxia is a cause of resistance to radiotherapy, especially in patients with
head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to …

Hypoxia, a condition of insufficient O 2 to support metabolism, occurs when the vascular
supply is interrupted, as in stroke or myocardial infarction, or when a tumor outgrows its …

Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …

Radiation therapy has gone through a series of revolutions in the last few decades and it is
now possible to produce highly conformal radiation dose distribution by using techniques …

The molecules known as bis (thiosemicarbazones) derived from 1, 2-diones can act as
tetradentate ligands for Cu (II), forming stable, neutral complexes. As a family, these …