Quinazolinones, the winning horse in drug discovery
AM Alsibaee, HM Al-Yousef, HS Al-Salem - Molecules, 2023 - mdpi.com
Quinazolines are nitrogen-containing heterocycles that consist of a benzene ring fused with
a pyrimidine ring. Quinazolinones, oxidized quinazolines, are promising compounds with a …
a pyrimidine ring. Quinazolinones, oxidized quinazolines, are promising compounds with a …
Tetramethylguanidine-functionalized melamine as a multifunctional organocatalyst for the expeditious synthesis of 1, 2, 4-triazoloquinazolinones
Abstract Novel nano-ordered 1, 1, 3, 3-tetramethylguanidine-functionalized melamine
(Melamine@ TMG) organocatalyst was prepared and adequately identified by various …
(Melamine@ TMG) organocatalyst was prepared and adequately identified by various …
Quinazolinone-amino acid hybrids as dual inhibitors of EGFR kinase and tubulin polymerization
Some fluoroquinazolinones (A–H) were designed, synthesized and biologically evaluated
for their antitumor activity against the two cell lines, MCF-7 and MDA-MBA-231. New …
for their antitumor activity against the two cell lines, MCF-7 and MDA-MBA-231. New …
Quinazoline pharmacophore in therapeutic medicine
OO Ajani, DV Aderohunmu, EN Umeokoro… - ||| Bangladesh …, 2016 - bdpsjournal.org
This present study comprehensively expatiates the functionalized utilization of quinazoline
scaffolds in drug development and furnishes latest updates in pharmacological …
scaffolds in drug development and furnishes latest updates in pharmacological …
[HTML][HTML] Modulation of peptidases by 2, 4-diamine-quinazoline derivative induces cell death in the amitochondriate parasite Trichomonas vaginalis
JI Weber, GV Rigo, DA Rocha, IS Fortes… - Biomedicine & …, 2021 - Elsevier
Trichomonas vaginalis is an amitochondriate protozoan and the agent of human
trichomoniasis, the most prevalent non-viral sexually transmitted infection (STI) in the world …
trichomoniasis, the most prevalent non-viral sexually transmitted infection (STI) in the world …
Synthesis and evaluation of anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities of some 3H-quinazolin-4-one derivatives
NNE El-Sayed, NM Almaneai… - Journal of enzyme …, 2019 - Taylor & Francis
Abstract Some new 3 H-quinazolin-4-one derivatives were synthesised and screened for
anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities …
anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities …
Design, synthesis, cytotoxic evaluation and molecular docking of new fluoroquinazolinones as potent anticancer agents with dual EGFR kinase and tubulin …
A series of new fluoroquinazolinone 6–8 and 10a–g derivatives was designed, prepared
and screened for their in vitro cytotoxic activity against human cancer cell lines MCF-7 and …
and screened for their in vitro cytotoxic activity against human cancer cell lines MCF-7 and …
Design, synthesis, antimicrobial and anti-biofilm evaluation, and molecular docking of newly substituted fluoroquinazolinones
Background: Quinazolines and quinazolinones derivatives are well known for their important
range of therapeutic activities. Objective: The study aims to carry out the synthesis of some …
range of therapeutic activities. Objective: The study aims to carry out the synthesis of some …
Design, synthesis, in-silico studies and apoptotic activity of novel amide enriched 2-(1H)-quinazolinone derivatives
Cancer is a broad classification of diseases that can affect any organ or body tissue due to
aberrant cellular proliferation for unknown reasons. Many present chemotherapeutic drugs …
aberrant cellular proliferation for unknown reasons. Many present chemotherapeutic drugs …
Multicomponent Preparation of Quinazolinone Derivatives in the Presence of TiO2 Nanoparticles Supported Ionic Liquids
R Bakhshali-Dehkordi, MA Ghasemzadeh… - Polycyclic Aromatic …, 2022 - Taylor & Francis
In this study, triazoloquinazolinone and benzimidazoquinazolinone derivatives have been
synthesized via a suitable and efficient procedure using one-pot multicomponent reactions …
synthesized via a suitable and efficient procedure using one-pot multicomponent reactions …