Mast-cell activation mediated by the high-affinity receptor for IgE (FcεRI) is considered to be
a key event in the allergic inflammatory response. However, in a physiological setting, other …

Mast cells have been recognized for well over 100 years. With time, human mast cells have
been documented to originate from CD34+ cells, and have been implicated in host …

Zinc is an essential trace element required for enzymatic activity and for maintaining the
conformation of many transcription factors; thus, zinc homeostasis is tightly regulated …

The high-affinity Fc receptor for IgE (FcεRI), a multimeric immune receptor, is a crucial
structure for IgE-mediated allergic reactions. In recent years, advances have been made in …

Mast cell mediator release represents a pivotal event in the initiation of inflammatory
reactions associated with allergic disorders. These responses follow antigen‐mediated …

Background Zeaxanthin is a carotenoid pigment found in several fruits and vegetables.
Belonging to the xanthophyll family, it is widely present in human and some animals skin …

The recent development of a consensus definition and proposed diagnostic criteria for
anaphylaxis offers promise for research efforts and a better understanding of the …

The mast cell is a central player in allergy and asthma. Activation of these cells induces the
release of preformed inflammatory mediators localized in specialized granules and the de …

Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but
also play a fundamental role in innate and adaptive immune responses to microbial …

Abstract CRACM1 (also called Orai1) constitutes the pore subunit of store-operated calcium
release–activated calcium channels. A point mutation in the gene encoding CRACM1 is …