Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding
ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many …

Although aortic stenosis is a common condition associated with major morbidity, mortality,
and health economic costs, there are currently no medical interventions capable of delaying …

Calcific aortic valve disease (CAVD) encompasses the range of disease from initial
alterations in the cell biology of the leaflets to end-stage calcification resulting in left …

The cardiac extracellular matrix (ECM) is a complex architectural network consisting of
structural and nonstructural proteins, creating strength and plasticity. The nonstructural …

The article gives an overview of phytic acid in food and of its significance for human nutrition.
It summarises phytate sources in foods and discusses problems of phytic acid/phytate …

Objectives. The aim of this study was to determine the prevalence of aortic sclerosis and
stenosis in the elderly and to identify clinical factors associated with degenerative aortic …

Calcification of the extracellular matrix (ECM) can be physiological or pathological.
Physiological calcification occurs in bone when the soft ECM is converted into a rigid …

Background Hyperlipidemia has been suggested as a risk factor for stenosis of the aortic
valve, but lipid-lowering studies have had conflicting results. Methods We conducted a …

Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study
the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent …

Calcification of the aortic valve is the third leading cause of heart disease in adults. The
incidence increases with age, and it is often associated with a bicuspid aortic valve present …