Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Several neurodevelopmental and neuropsychiatric disorders are characterized by
intermittent episodes of pathological activity. Although genetic therapies offer the ability to …

The last decade saw impressive advances not only in the discovery of gene mutations
causing epilepsy, but also in unraveling the molecular mechanisms underlying the clinical …

KCNMA1 encodes the pore-forming α subunit of the “Big K+”(BK) large conductance calcium
and voltage-activated K+ channel. BK channels are widely distributed across tissues …

Recent data support the use of behavioural and psychological interventions for social
communication and anxiety in ASD; data are more limited regarding pharmacotherapy for …

Epilepsy is a major health burden, calling for new mechanistic insights and therapies.
CRISPR-mediated gene editing shows promise to cure genetic pathologies, although …

In the healthy brain, neuronal excitability and synaptic strength are homeostatically
regulated to keep neuronal network activity within physiological boundaries. Epilepsy is …

Dravet Syndrome is a genetic epileptic syndrome characterized by severe and intractable
seizures associated with cognitive, motor, and behavioral impairments. The disease is also …

Gene therapy may constitute a promising alternative to conventional pharmacological tools
and surgeries for epilepsy. For primary epilepsy, a single variant leading to a significant …