Colorectal cancer is the third most common malignancy in men and the second most
common cancer in women. Despite the success of screening programs and the …

GTPases and kinases are two predominant signaling modules that regulate cell fate.
Dysregulation of Ras, a GTPase, and the three eponymous kinases that form key nodes of …

AIM: To investigate gene mutations and DNA mismatch repair (MMR) protein abnormality in
Chinese colorectal carcinoma (CRC) patients and their correlations with clinicopathologic …

ROA, Iván; SANCHEZ, Tamara; MAJLIS, Alejandro y SCHALPER, Kurt. KRAS gene mutation
in colorectal cancer. Rev. méd. Chile [online]. 2013, vol. 141, n. 9, pp. 1166-1172. ISSN …

Background KRAS mutations are common in colorectal cancer (CRC). The role of KRAS
mutation status as a prognostic factor remains controversial, and most large population …

Background Patients with colorectal cancer can benefit from anti-EGFR (epidermal growth
factor receptor) therapy. However, this therapy is not effective for treating colorectal cancers …

Sporadic colorectal cancer (CRC) is classified into several molecular subtypes. We
previously established two groups of DNA methylation markers through genome‐wide DNA …

Background: In patients with high-stage colorectal carcinomas (CRC), anti-EGFR therapy is
known to be effective only in cases with a wildtype K-ras gene status. Different procedures …

RAS oncogene family members are molecular switches of signaling pathways that control
cell growth, proliferation, differentiation, and survival. In colorectal cancer, Kirsten-RAS …

In order to make a comprehensive assessment of the potential association between one
genetic variant in the insulin receptor substrate 1 (IRS-1) gene, rs1801278, and colorectal …