Alzheimer's disease

JAS Lopez, HM González, GC Léger - Handbook of clinical neurology, 2019 - Elsevier
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and
functional decline associated with age together with a particular neuropathology. It was first …

Molecular mechanisms underlying protective role of quercetin in attenuating Alzheimer's disease

E Zaplatic, M Bule, SZA Shah, MS Uddin, K Niaz - Life sciences, 2019 - Elsevier
Quercetin belongs to the flavonoids family, which is present in most of the plants including
fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available …

[HTML][HTML] Insulin resistance and Alzheimer's disease: bioenergetic linkages

BJ Neth, S Craft - Frontiers in aging neuroscience, 2017 - frontiersin.org
Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced
by brain glucose hypometabolism that can be observed potentially decades prior to the …

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease

G Ganguly, S Chakrabarti, U Chatterjee… - Drug design …, 2017 - Taylor & Francis
Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases
of the elderly people that have devastating effects in terms of morbidity and mortality. The …

[HTML][HTML] Linking oxidative stress and proteinopathy in Alzheimer's disease

C Sharma, SR Kim - Antioxidants, 2021 - mdpi.com
Proteinopathy and excessive production of reactive oxygen species (ROS), which are the
principal features observed in the Alzheimer's disease (AD) brain, contribute to neuronal …

The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease

DA Drachman - Alzheimer's & Dementia, 2014 - Elsevier
The “amyloid hypothesis” has dominated Alzheimer research for more than 20 years, and
proposes that amyloid is the toxic cause of neural/synaptic damage and dementia. If correct …

Nootropic and anti-Alzheimer's actions of medicinal plants: molecular insight into therapeutic potential to alleviate Alzheimer's neuropathology

MS Uddin, A Al Mamun, MT Kabir, M Jakaria… - Molecular …, 2019 - Springer
Medicinal plants are the backbone of modern medicine. In recent times, there is a great urge
to discover nootropic medicinal plants to reverse cognitive dysfunction owing to their less …

[HTML][HTML] Metabolic risk factors of sporadic Alzheimer's disease: implications in the pathology, pathogenesis and treatment

S Chakrabarti, VK Khemka, A Banerjee… - Aging and …, 2015 - ncbi.nlm.nih.gov
Abstract Alzheimer's disease (AD), the major cause of dementia among the elderly world-
wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority …

[HTML][HTML] Micropublications: a semantic model for claims, evidence, arguments and annotations in biomedical communications

T Clark, PN Ciccarese, CA Goble - Journal of biomedical semantics, 2014 - Springer
Background Scientific publications are documentary representations of defeasible
arguments, supported by data and repeatable methods. They are the essential mediating …

[HTML][HTML] Amyloid-beta aggregation implicates multiple pathways in Alzheimer's disease: Understanding the mechanisms

MO Iliyasu, SA Musa, SB Oladele, AI Iliya - Frontiers in Neuroscience, 2023 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by tau
pathology and accumulations of neurofibrillary tangles (NFTs) along with amyloid-beta (Aβ) …