A feature in the pathophysiology of major depressive disorder (MDD), a mood disorder, is
the impairment of excitatory synapses in the prefrontal cortex. Intriguingly, different types of …

Brown and white adipose tissues are essential for maintenance of proper energy balance
and metabolic health. In order to function efficiently, these tissues require both endocrine …

Although ubiquitous in biological studies, the enhanced green and yellow fluorescent
proteins (EGFP and EYFP) were not specifically optimized for neuroscience, and their …

Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner.
To accomplish this, tau must cross cell-limiting membranes, a process that is poorly …

Mechanical stimulation modulates neural development and neuronal activity. In a previous
study, magnetic “nano‐pulling” is proposed as a tool to generate active forces. By loading …

Human brain is undoubtedly the most complex organ in the body. Thus, it is difficult to
develop adequate and at the same time human relevant test systems and models to cover …

Background Ca 2+-imaging is a powerful tool to measure neuronal dynamics and network
activity. To monitor network-level changes in cultured neurons, neuronal activity is often …

Plethora of research has shed light on the critical role of synaptic dysfunction in various
neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), Parkinson's …

Transcription factors Satb1 and Satb2 are involved in the processes of cortex development
and maturation of neurons. Alterations in the expression of their target genes can lead to …

Methods for patterning neurons in vitro have gradually improved and are used to investigate
questions that are difficult to address in or ex vivo. Though these techniques guide axons …