Neuroprosthetics: from sensorimotor to cognitive disorders

A Gupta, N Vardalakis, FB Wagner - Communications biology, 2023 - nature.com
Neuroprosthetics is a multidisciplinary field at the interface between neurosciences and
biomedical engineering, which aims at replacing or modulating parts of the nervous system …

The science and engineering behind sensitized brain-controlled bionic hands

C Pandarinath, SJ Bensmaia - Physiological Reviews, 2022 - journals.physiology.org
Advances in our understanding of brain function, along with the development of neural
interfaces that allow for the monitoring and activation of neurons, have paved the way for …

Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation

G Valle, N Katic Secerovic, D Eggemann… - Nature …, 2024 - nature.com
Artificial communication with the brain through peripheral nerve stimulation shows promising
results in individuals with sensorimotor deficits. However, these efforts lack an intuitive and …

Neuromorphic hardware for somatosensory neuroprostheses

E Donati, G Valle - Nature Communications, 2024 - nature.com
In individuals with sensory-motor impairments, missing limb functions can be restored using
neuroprosthetic devices that directly interface with the nervous system. However, restoring …

Activity-dependent recruitment of inhibition and excitation in the awake mammalian cortex during electrical stimulation

MC Dadarlat, YJ Sun, MP Stryker - Neuron, 2024 - cell.com
Electrical stimulation is an effective tool for mapping and altering brain connectivity, with
applications ranging from treating pharmacology-resistant neurological disorders to …

In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation

SP Savya, F Li, S Lam, SM Wellman, KC Stieger… - Biomaterials, 2022 - Elsevier
Brain computer interfaces (BCIs), including penetrating microelectrode arrays, enable both
recording and stimulation of neural cells. However, device implantation inevitably causes …

Intracortical somatosensory stimulation to elicit fingertip sensations in an individual with spinal cord injury

MS Fifer, DP McMullen, LE Osborn, TM Thomas… - Neurology, 2022 - AAN Enterprises
Background and Objectives The restoration of touch to fingers and fingertips is critical to
achieving dexterous neuroprosthetic control for individuals with sensorimotor dysfunction …

Microstimulation of human somatosensory cortex evokes task-dependent, spatially patterned responses in motor cortex

ND Shelchkova, JE Downey, CM Greenspon… - Nature …, 2023 - nature.com
The primary motor (M1) and somatosensory (S1) cortices play critical roles in motor control
but the signaling between these structures is poorly understood. To fill this gap, we recorded …

Dynamic amplitude modulation of microstimulation evokes biomimetic onset and offset transients and reduces depression of evoked calcium responses in sensory …

C Hughes, T Kozai - Brain stimulation, 2023 - Elsevier
Background Intracortical microstimulation (ICMS) is an emerging approach to restore
sensation to people with neurological injury or disease. Biomimetic microstimulation, or …

Neural plasticity in sensorimotor brain–machine interfaces

MC Dadarlat, RA Canfield… - Annual review of …, 2023 - annualreviews.org
Brain–machine interfaces (BMIs) aim to treat sensorimotor neurological disorders by
creating artificial motor and/or sensory pathways. Introducing artificial pathways creates new …