Challenges in the development of soft sensors for bioprocesses: A critical review
Among the greatest challenges in soft sensor development for bioprocesses are variable
process lengths, multiple process phases, and erroneous model inputs due to sensor faults …
process lengths, multiple process phases, and erroneous model inputs due to sensor faults …
A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing
As competition in the biopharmaceutical market gets keener due to the market entry of
biosimilars, process analytical technologies (PATs) play an important role for process …
biosimilars, process analytical technologies (PATs) play an important role for process …
Developments and opportunities in continuous biopharmaceutical manufacturing
O Khanal, AM Lenhoff - MAbs, 2021 - Taylor & Francis
Today's biologics manufacturing practices incur high costs to the drug makers, which can
contribute to high prices for patients. Timely investment in the development and …
contribute to high prices for patients. Timely investment in the development and …
Integration and digitalization in the manufacturing of therapeutic proteins
H Narayanan, M Sponchioni, M Morbidelli - Chemical Engineering Science, 2022 - Elsevier
The biopharmaceutical market has experienced a tremendous growth in the last years.
However, this growth should be balanced considering the difficulty in bioproduct …
However, this growth should be balanced considering the difficulty in bioproduct …
AI-ML applications in bioprocessing: ML as an enabler of real time quality prediction in continuous manufacturing of mAbs
As continuous manufacturing of biotherapeutics gains steam, there is an increasing interest
in using machine learning (ML) techniques for real time prediction of product quality and for …
in using machine learning (ML) techniques for real time prediction of product quality and for …
[HTML][HTML] Digitization in bioprocessing: The role of soft sensors in monitoring and control of downstream processing for production of biotherapeutic products
Owing to the advancement in the technologies, the vision of smart manufacturing is not
implausible. Development of sophisticated measuring tools, modelling approaches …
implausible. Development of sophisticated measuring tools, modelling approaches …
Anything but conventional chromatography approaches in bioseparation
While packed bed chromatography, known as conventional chromatography, has been
serving the biopharmaceutical industry for decades as the bioseparation method of choice …
serving the biopharmaceutical industry for decades as the bioseparation method of choice …
Continuous integrated manufacturing for biopharmaceuticals: A new paradigm or an empty promise?
Continuous integrated bioprocessing has elicited considerable interest from the biopharma
industry for the many purported benefits it promises. Today many major biopharma …
industry for the many purported benefits it promises. Today many major biopharma …
Challenges in process control for continuous processing for production of monoclonal antibody products
Continuous processing has been garnering much interest lately for production of
biopharmaceutical products. Purported benefits include higher productivity (10-15X) …
biopharmaceutical products. Purported benefits include higher productivity (10-15X) …
[HTML][HTML] Applications of machine learning in antibody discovery, process development, manufacturing and formulation: Current trends, challenges, and opportunities
TT Khuat, R Bassett, E Otte, A Grevis-James… - Computers & Chemical …, 2024 - Elsevier
While machine learning (ML) has made significant contributions to the biopharmaceutical
field, its applications are still in the early stages in terms of providing direct support for quality …
field, its applications are still in the early stages in terms of providing direct support for quality …