Autoimmune T cell responses directed against insulin-producing β cells are central to the
pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to …

It is being increasingly recognized that a dysregulation of the immune system plays a vital
role in neurological disorders and shapes the treatment of the disease. Aberrant T cell …

Cytotoxic CD8 T lymphocytes play a central role in the tissue destruction of many
autoimmune disorders. In type 1 diabetes (T1D), insulin and its precursor preproinsulin are …

Abstract Objective: Aquaporin 4 (AQP4)‐specific autoantibodies in neuromyelitis optica
(NMO) are immunoglobulin (Ig) G1, a T cell‐dependent Ig subclass, indicating that AQP4 …

Chimeric antigen receptor (CAR)-expressing T cells targeting B-cell maturation antigen
(BCMA) have activity against multiple myeloma, but improvements in anti-BCMA CARs are …

Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain
elusive. While the importance of cellular immunity has been shown in mice, T cell responses …

Ag-specific CD4+ T cells orchestrating adaptive immune responses are crucial for the
development of protective immunity, but also mediate immunopathologies. To date …

Type 1 diabetes (T1D) develops when insulin-secreting β-cells, found in the pancreatic islets
of Langerhans, are destroyed by infiltrating T cells. How human T cells recognize β-cell …

HLA-DQ8, a genetic risk factor in type I diabetes (T1D), presents hybrid insulin peptides
(HIPs) to autoreactive CD4+ T cells. The abundance of spliced peptides binding to HLA-DQ8 …

Although studies with primary lymphocytes are almost always conducted in CO2 incubators
maintained at atmospheric oxygen levels (atmosO2; 20%), the physiological oxygen levels …