Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius
var. Caesius and belongs to the anthracyclines family. The anti-cancer activity of Dox is …

Purpose Although doxorubicin chemotherapy is commonly applied for treating different
malignant tumors, cardiotoxicity induced by this chemotherapeutic agent restricts its clinical …

The glutathione (GSH) system is considered to be one of the most powerful endogenous
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …

The utility of anthracycline antineoplastic agents in the clinic is compromised by the risk of
cardiotoxicity. It has been calculated that approximately 10% of patients treated with …

Background Doxorubicin, an anthracycline chemotherapeutic agent, is widely used in the
treatment of many cancers. However, doxorubicin posts a great risk of adverse …

Resveratrol is a naturally occurring polyphenol that provides a number of anti-aging health
benefits including improved metabolism, cardioprotection, and cancer prevention. Much of …

Cardiovascular disease is the leading cause of death worldwide. Despite advancements in
diagnosis and treatment of cardiovascular disease, the incidence of cardiovascular disease …

Due to the aging of the populations of developed countries and a common occurrence of risk
factors, it is increasingly probable that a patient may have both cancer and cardiovascular …

Globally, breast cancer is the most frequently diagnosed cancer among women. The major
unresolved problems with metastatic breast cancer is recurrence after receiving objective …

Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its
cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in …