Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous
drinking, defined by quantity and frequency of consumption, is associated with acute and …

Alcohol is a major contributor to global disease and a leading cause of preventable death,
causing approximately 88,000 deaths annually in the United States alone. Alcohol use …

Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

The prevalence of alcohol use disorder (AUD) has been steadily increasing over the past
decade. In parallel, alcohol-associated liver disease (ALD) has been increasing at an …

Baclofen is an effective therapeutic for the treatment of spasticity related to multiple sclerosis,
spinal cord injuries, and other spinal cord pathologies. It has been increasingly used off …

Alcohol-related liver disease (ALD) refers to the liver damage occurring due to excessive
alcohol consumption and involves a broad spectrum of diseases that includes liver steatosis …

Summary of recommendations and levels of evidence Chapter 2: Screening and
assessment for unhealthy alcohol use Screening Screening for unhealthy alcohol use and …

Non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD), both of
them accounting for fatty liver disease (FLD), are among the most common chronic liver …

Alcohol-associated liver disease (ALD) is the most common cause of cirrhosis and liver-
related mortality in many regions worldwide. Around 75% of patients with cirrhosis are …

Identification of new medications for alcohol use disorder (AUD) is important for improving
treatment options. Baclofen, a GABAB agonist, has been identified as a potential …