Cell and circuit complexity of the external globus pallidus

CD Courtney, A Pamukcu, CS Chan - Nature neuroscience, 2023 - nature.com
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …

Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease

W Xu, J Wang, XN Li, J Liang, L Song, Y Wu… - Translational …, 2023 - Springer
Deep brain stimulation (DBS) is a well-established and effective treatment for patients with
advanced Parkinson's disease (PD), yet its underlying mechanisms remain enigmatic …

Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson's disease and essential tremor

M Scherer, LA Steiner, SK Kalia… - Proceedings of the …, 2022 - National Acad Sciences
Deep brain stimulation procedures offer an invaluable opportunity to study disease through
intracranial recordings from awake patients. Here, we address the relationship between …

[HTML][HTML] Corticostriatal pathways for bilateral sensorimotor functions

R Gómez-Ocádiz, G Silberberg - Current Opinion in Neurobiology, 2023 - Elsevier
Corticostriatal pathways are essential for a multitude of motor, sensory, cognitive, and
affective functions. They are mediated by cortical pyramidal neurons, roughly divided into …

A role for the subthalamic nucleus in aversive learning

GP Serra, A Guillaumin, B Vlcek, L Delgado-Zabalza… - Cell Reports, 2023 - cell.com
The subthalamic nucleus (STN) is critical for behavioral control; its dysregulation
consequently correlated with neurological and neuropsychiatric disorders, including …

The anterior cingulate cortex controls the hyperactivity in subthalamic neurons in male mice with comorbid chronic pain and depression

YD Wang, ST Bao, Y Gao, J Chen, T Jia, C Yin… - PLoS …, 2024 - journals.plos.org
Neurons in the subthalamic nucleus (STN) become hyperactive following nerve injury and
promote pain-related responses in mice. Considering that the anterior cingulate cortex …

Rethinking the external globus pallidus and information flow in cortico‐basal ganglia‐thalamic circuits

C Giossi, JE Rubin, A Gittis… - European Journal of …, 2024 - Wiley Online Library
For decades, the external globus pallidus (GPe) has been viewed as a passive way‐station
in the indirect pathway of the cortico‐basal ganglia‐thalamic (CBGT) circuit, sandwiched …

A framework for translational therapy development in deep brain stimulation

JZ Chen, J Volkmann, CW Ip - npj Parkinson's Disease, 2024 - nature.com
Deep brain stimulation (DBS) is an established treatment for motor disorders like
Parkinson's disease, but its mechanisms and effects on neurons and networks are not fully …

Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum

C Giossi, J Bahuguna, JE Rubin, T Verstynen… - Proceedings of the …, 2024 - pnas.org
Reactive inhibitory control is crucial for survival. Traditionally, this control in mammals was
attributed solely to the hyperdirect pathway, with cortical control signals flowing …

Connecto-informatics at the mesoscale: current advances in image processing and analysis for mapping the brain connectivity

YK Choi, L Feng, WK Jeong, J Kim - Brain Informatics, 2024 - Springer
Mapping neural connections within the brain has been a fundamental goal in neuroscience
to understand better its functions and changes that follow aging and diseases …