Cell and circuit complexity of the external globus pallidus
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease
W Xu, J Wang, XN Li, J Liang, L Song, Y Wu… - Translational …, 2023 - Springer
Deep brain stimulation (DBS) is a well-established and effective treatment for patients with
advanced Parkinson's disease (PD), yet its underlying mechanisms remain enigmatic …
advanced Parkinson's disease (PD), yet its underlying mechanisms remain enigmatic …
Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson's disease and essential tremor
Deep brain stimulation procedures offer an invaluable opportunity to study disease through
intracranial recordings from awake patients. Here, we address the relationship between …
intracranial recordings from awake patients. Here, we address the relationship between …
[HTML][HTML] Corticostriatal pathways for bilateral sensorimotor functions
R Gómez-Ocádiz, G Silberberg - Current Opinion in Neurobiology, 2023 - Elsevier
Corticostriatal pathways are essential for a multitude of motor, sensory, cognitive, and
affective functions. They are mediated by cortical pyramidal neurons, roughly divided into …
affective functions. They are mediated by cortical pyramidal neurons, roughly divided into …
A role for the subthalamic nucleus in aversive learning
GP Serra, A Guillaumin, B Vlcek, L Delgado-Zabalza… - Cell Reports, 2023 - cell.com
The subthalamic nucleus (STN) is critical for behavioral control; its dysregulation
consequently correlated with neurological and neuropsychiatric disorders, including …
consequently correlated with neurological and neuropsychiatric disorders, including …
The anterior cingulate cortex controls the hyperactivity in subthalamic neurons in male mice with comorbid chronic pain and depression
YD Wang, ST Bao, Y Gao, J Chen, T Jia, C Yin… - PLoS …, 2024 - journals.plos.org
Neurons in the subthalamic nucleus (STN) become hyperactive following nerve injury and
promote pain-related responses in mice. Considering that the anterior cingulate cortex …
promote pain-related responses in mice. Considering that the anterior cingulate cortex …
Rethinking the external globus pallidus and information flow in cortico‐basal ganglia‐thalamic circuits
For decades, the external globus pallidus (GPe) has been viewed as a passive way‐station
in the indirect pathway of the cortico‐basal ganglia‐thalamic (CBGT) circuit, sandwiched …
in the indirect pathway of the cortico‐basal ganglia‐thalamic (CBGT) circuit, sandwiched …
A framework for translational therapy development in deep brain stimulation
JZ Chen, J Volkmann, CW Ip - npj Parkinson's Disease, 2024 - nature.com
Deep brain stimulation (DBS) is an established treatment for motor disorders like
Parkinson's disease, but its mechanisms and effects on neurons and networks are not fully …
Parkinson's disease, but its mechanisms and effects on neurons and networks are not fully …
Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum
Reactive inhibitory control is crucial for survival. Traditionally, this control in mammals was
attributed solely to the hyperdirect pathway, with cortical control signals flowing …
attributed solely to the hyperdirect pathway, with cortical control signals flowing …
Connecto-informatics at the mesoscale: current advances in image processing and analysis for mapping the brain connectivity
Mapping neural connections within the brain has been a fundamental goal in neuroscience
to understand better its functions and changes that follow aging and diseases …
to understand better its functions and changes that follow aging and diseases …