Phenotypic plasticity can serve as a stepping stone towards adaptation. Recently, studies
have shown that gene expression contributes to emergent stress responses such as thermal …

Isogenic cells in a common environment present a large degree of heterogeneity in gene
expression. Part of this variability is attributed to transcriptional bursting: the stochastic …

INTRODUCTION Fluctuations have long been known to dynamically shape microstate
distributions in physical systems. Throughout engineering,“dithering” approaches that …

A common approach to benchmarking of single-cell transcriptomics tools is to generate
synthetic datasets that statistically resemble experimental data. However, most existing …

The abundance of new computational methods for processing and interpreting
transcriptomes at a single cell level raises the need for in silico platforms for evaluation and …

Shadow enhancers, groups of seemingly redundant enhancers, are found in a wide range of
organisms and are critical for robust developmental patterning. However, their mechanism of …

Inside individual cells, protein population counts are subject to molecular noise due to low
copy numbers and the inherent probabilistic nature of biochemical processes. We …

Gene-expression bimodality, as a potential mechanism generating phenotypic cell diversity,
can enhance the survival of cells in a fluctuating environment. Previous studies have shown …

Noisy gene expression generates diverse phenotypes, but little is known about mechanisms
that modulate noise. Combining experiments and modeling, we studied how tumor necrosis …

RNA polymerase II initiates transcription either randomly or in bursts. We examined the light-
dependent transcriptional activator White Collar Complex (WCC) of Neurospora to …