Although the pathobiology of atherosclerosis is a complex multifactorial process, blood flow-
induced shear stress has emerged as an essential feature of atherogenesis. This fluid drag …

Lipid rafts are subdomains of the plasma membrane that contain high concentrations of
cholesterol and glycosphingolipids. They exist as distinct liquid-ordered regions of the …

The cell biology of caveolae is a rapidly growing area of biomedical research. Caveolae are
known primarily for their ability to transport molecules across endothelial cells, but modern …

Endothelial cells (EC) form a unique signal-transducing surface in the vascular system. The
abundance of ion channels in the plasma membrane of these nonexcitable cells has raised …

Caveolae are vesicular invaginations of the plasma membrane. The chief structural proteins
of caveolae are the caveolins. Caveolins form a scaffold onto which many classes of …

Although nitric oxide (NO) 1 may not modulate all cellular functions and may not be present
in all mammalian cells, the sheer volume of publications on the subject might lead one to …

GnRH and its analogs are used extensively for the treatment of hormone-dependent
diseases and assisted reproductive techniques. They also have potential as novel …

Phosphoinositide-specific phospholipase C (PLC) subtypes β, γ, and δ comprise a related
group of multidomain phosphodiesterases that cleave the polar head groups from inositol …

Nitric oxide (NO) is produced from virtually all cell types composing the myocardium and
regulates cardiac function through both vascular-dependent and-independent effects. The …

Sequestration of G protein-coupled receptors from the cell surface is a commonly observed
phenomenon following agonist-stimulation. This process is now believed to be important for …